Neopterin, β2-Microglobulin,and Acute Phase Proteins in HIV-1-Seropositive and -Seronegative Zambian Patients with Tuberculosis |
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| Authors: | M. Hosp A. M. Elliott J. G. Raynes A. G. Mwinga N. Luo R. Zangerle J. O. M. Pobee H. Wachter M. P. Dierich K. P. W. J. McAdam D. Fuchs |
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| Affiliation: | (1) London School of Tropical Medicine and Hygiene, London, UK, GB;(2) School of Medicine, University of Zambia, Lusaka, Zambia, ZM;(3) Department of Venerology and Dermatology, University of Innsbruck, Innsbruck, Austria, AT;(4) Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Innsbruck, Austria, AT;(5) Institute of Hygiene, University of Innsbruck, Innsbruck, Austria, AT;(6) Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria, AT |
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| Abstract: | Neopterin is a biochemical marker for the activation of the cell-mediated immune system. We measured neopterin, β2-microglobulin, and acute phase proteins in 31 HIV-seropositive and -seronegative Zambian patients with tuberculosis, using stored sera that had been obtained at the beginning and at end of antituberculosis treatment. In both HIV-seropositive and -seronegative patients neopterin and acute phase proteins were elevated when tuberculosis was initially diagnosed and fell during treatment. In contrast, the mean β2-microglobulin level increased during antituberculous therapy in the HIV-seropositive group. Serum neopterin levels at diagnosis were correlated with other parameters of disease activity (fever, anemia, and weight loss). In both groups, patients with persistently elevated neopterin levels at the end of treatment were more likely to suffer relapse of tuberculosis or other adverse health events in the subsequent follow-up period. Neopterin can be used to monitor the response to antituberculous therapy in both HIV-seropositive and -seronegative patients and may have a prognostic value for the patients' wellbeing in the follow-up period. Accepted for publication: 13 December 1996 |
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| Keywords: | : Neopterin— β 2-Microglobulin— Tuberculosis— Human immunodeficiency virus. |
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