影响肺癌相关肿瘤标志物因素分析

目的　探讨肺癌相关肿瘤标志物 (tumor marker,TM)的影响因素 ,包括癌胚抗原 (CEA)、细胞角蛋白(CA2 1- 2 )、神经原特异性烯醇化酶 (NSE)和鳞癌细胞抗原 (SCC)。方法　对血清 TM水平明显升高的 95例非肿瘤患者的临床资料进行分析。结果　中、重度肺部感染患者 ,治疗前血清 CEA、CA2 1- 1、NSE和 SCC平均水平分别为2 8.6 6、7.5 0、32 .2 8和 3.19。感染控制后其数值下降至 12 .90、3.33、14 .85和 1.30 (p均 <0 .0 0 1)。良性肝、肾疾病治疗前后的血清 TM水平也有统计学差异。结论　中、重度肺部感染和良性肝、肾疾病可使血清 TM水平显著升高 ,感染控制及病情好转后 ,血清 TM水平降至正常

The Analysis of Possible Factors Affecting the Serum Levels of Lung-Cancer-related Tumor Makers

Objective To explore the possible factors including the serum levels of CEA, CA21 1, NSE and SCC as representing the lung cancer related tumor markers.Methods Clinical data of 95 patients who showed higher level of tumor markers but no evidence of lung cancer were collected and analyzed.Results The mean pre treatment levels of CEA, CA21 1, NSE and SCC among the patients with medium or higher level of lung infection were 28.66, 7.5, 32.28 and 3.19 ng/ml, respectively. The levels decreased, respectively, to 12.90, 3.33, 14.85, and 1.30 after the control of the infection (p < .001 for each comparison). The patients with abnormal liver or kidney function also showed significantly high levels of tumor markers. The levels of tumor markers became normal after recuperation.Conclusion Lung infection, abnormal liver or kidney function may represent some risk factors as evidenced by the increment of levels of tumor markers.