Targeting adiponectin for cardioprotection |
| |
Authors: | Ouchi Noriyuki Shibata Rei Walsh Kenneth |
| |
Institution: | Molecular Cardiology/Whitaker Cardiovascular Institute, Boston University School of Medicine, 715 Albany Street, W611, Boston, MA 02118, USA. |
| |
Abstract: | Adiponectin is an adipose tissue-derived plasma protein which has a reduced concentration in subjects with obesity-related diseases. Adiponectin has antidiabetic and anti-inflammatory characteristics, which lead to beneficial actions on various obesity-linked complications. Recent experimental findings have shown that adiponectin contributes to protection against cardiac remodelling after pressure overload and cardiac injury following ischaemia-reperfusion. Thus, adiponectin could emerge as a potential cardioprotective agent for the treatment of several pathological heart conditions. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|