吗啡耐受猴脑内葡萄糖代谢的显像研究

目的:研究猴脑内对吗啡耐受敏感的神经定位,探讨吗啡耐受的可能机制。方法:选择健康猴5只,采用PHILIPS CPET Plus扫描仪行PET扫描,观察正常脑内各区的葡萄糖代谢率(CMRGlu)。每天肌肉注射吗啡10mg/kg,连续1周,使猴对吗啡产生耐受,然后再次行PET扫描,观察吗啡耐受后脑内各区的CMRGlu。比较两次扫描脑内各区CMRGlu的变化情况。在两次扫描的横断面上分别划出8个断面,每一断面划出全脑范围的感兴趣区(ROI),并分别划出额叶、颞叶、枕叶、顶叶、丘脑、基底核、纹状体、扣带回、桥脑、海马和小脑等脑区ROI,计算各ROI内平均每像素点的计数。结果:(1)吗啡耐受前全脑内CMRGlu计数2119±114,耐受后计数为1721±105,显著降低(P<0.05)。(2)与吗啡耐受前比较,耐受后扣带回、桥脑和基底核CMRGlu计数降低(P<0.01),分别由3307±157、3114±104和3038±138降至2029±108、2176±136和2126±115,降低38.6%、30.1%和30.0%,但其他脑功能区无显著变化。结论:长期使用吗啡对猴脑葡萄糖代谢具有一定的抑制作用,尤以扣带回、桥...

Study on cerebral glucose metabolism for morphine tolerance in monkey

Objective To study the targets of morphine tolerance in monkey,and to probe the mechanism of morphine tolerance.Methods 5 healthy monkeys were scanned by PHILIPS CPET Plus scanner to observe normal glucose metabolism of various regional brain areas and then were injected 10 mg/kg morphine once a day(lasting one week) to establish morphine tolerance model.After one week morphin injection,these monkeys were scanned to observe glucose metabolism of various regional brain areas again.Results(1)Whole brain gluco...