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Treatment outcomes of macrolide-susceptible Mycobacterium abscessus lung disease |
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| Authors: | Hayoung Choi Byung Woo Jhun Su-Young Kim Dae Hun Kim Hyun Lee Kyeongman Jeon O Jung Kwon Hee Jae Huh Chang-Seok Ki Nam Yong Lee Sung Jae Shin Charles L Daley Won-Jung Koh |
| Institution: | 1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;2. Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;3. Department of Microbiology and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea;4. Division of Mycobacterial and Respiratory Infections, Department of Medicine, National Jewish Health, Denver, CO, United States |
| Abstract: | Mycobacterium abscessus lung disease is difficult to treat due to inducible resistance to macrolides. However, 15%–20% of isolates are macrolide susceptible. In 14 patients with macrolide-susceptible M. abscessus lung disease, all isolates had nonfunctional erm(41) gene, and sputum culture conversion rate was achieved in 93% (13/14) following antibiotic therapy. |
| Keywords: | Nontuberculous mycobacteria Macrolides Drug resistance Treatment |
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