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Sanger sequencing versus INNO-LiPA® HBV PreCore assay for routine detection of precore and basal core promoter mutations in hepatitis virus B chronically infected patients |
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| Authors: | EK Alidjinou L Bocket V Pigot V Lambert C Hallaert V Canva D Hober |
| Institution: | 1. Univ Lille, Faculté de Médecine, CHU Lille, Laboratoire de Virologie EA3610, F-59000, Lille, France;2. CHU de Lille, Service des Maladies de l''appareil Digestif, Lille, France |
| Abstract: | We compared the Sanger sequencing and the commercial INNO-LiPA® HBV assay for the routine detection of precore (PC) and basal core promoter (BCP) mutations of hepatitis B virus in chronically infected patients. The overall agreement rate between assays was 94.2% and 98.8% for the detection of PC and BCP mutations, respectively. |
| Keywords: | Hepatitis B virus Precore Basal core promoter Mutations Sanger sequencing INNO-LiPA® |
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