Subtypes A,C, G,and recombinant HIV type 1 are circulating in Bangladesh |
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Authors: | Ljungberg Karl Hassan Mohammed Sawkat Islam Mohammad Nazrul Siddiqui Mahbub Alam Aziz Mohammad Monowar Wahren Britta Islam Khalid Bin Leitner Thomas |
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Institution: | Swedish Institute for Infectious Disease Control, and Microbiology and Tumor Biology Center, Karolinska Institute, SE-171 82 Solna, Sweden. |
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Abstract: | We analyzed the genetic diversity of HIV-1 circulating in Bangladesh by direct sequencing and subsequent phylogenetic analysis of the V3 region of the env gene and p17 fragment of the gag gene from nine unrelated patients. The sequences from one sample grouped into subtype A, five samples grouped into subtype C, and one grouped into subtype G. In addition, two patients appeared to be infected with different recombinant viruses consisting of subtype A and unclassifiable viral sequences. Epidemiological analysis revealed heterosexual transmission in the majority of cases. Furthermore, most subjects had a history of traveling, either to India or to the Arabian Peninsula. This study shows that several HIV-1 subtypes are circulating in Bangladesh, and we conclude that there must have been several introductions of HIV-1 into the Bangladeshi population. |
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