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SDF-1/CXCR4轴与白血病血管新生研究进展
引用本文:包萃华,贺其图. SDF-1/CXCR4轴与白血病血管新生研究进展[J]. 中国实验血液学杂志, 2008, 16(2): 447-451
作者姓名:包萃华  贺其图
作者单位:内蒙古包头医学院第一附属医院血液科,内蒙古包头,014010
摘    要:基质细胞衍生因子-1(SDF-1)及其受体CXCR4所构成的SDF-1/CXCR4轴生物效应的研究近些年来进展迅速,其在肿瘤发生及发展中起重要作用,并与肿瘤血管新生密切相关,本文就SDF-1及其受体CXCR4,SDF-1/CXCR4轴在白血病细胞中的表达,SDF-1/CXCR4轴与白血病血管新生的关系,抗SDF-1/CXCR4抑制剂在血管新生治疗中的应用的研究进展加以综述。

关 键 词:白血病  SDF-1/CXCR4轴  血管新生
文章编号:1009-2137(2008)02-0447-05
修稿时间:2007-03-20

Advance of Research on SDF-1/CXCR4 Axis and Angiogenesis in Leukemia——Review
BAO Cui-Hua,HE Qi-Tu. Advance of Research on SDF-1/CXCR4 Axis and Angiogenesis in Leukemia——Review[J]. Journal of experimental hematology, 2008, 16(2): 447-451
Authors:BAO Cui-Hua  HE Qi-Tu
Affiliation:Department of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China.
Abstract:The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on.
Keywords:leukemia  SDF-1/CXCR axis  angiogenesis
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