| SDF-1／CXCR4轴与白血病血管新生研究进展 |
| |
| 引用本文： | 包萃华,贺其图.SDF-1／CXCR4轴与白血病血管新生研究进展[J].中国实验血液学杂志,2008,16(2):447-451. |
| |
| 作者姓名： | 包萃华 贺其图 |
| |
| 作者单位： | 内蒙古包头医学院第一附属医院血液科,内蒙古包头,014010 |
| |
| 摘 要： | 基质细胞衍生因子-1（SDF-1）及其受体CXCR4所构成的SDF-1／CXCR4轴生物效应的研究近些年来进展迅速，其在肿瘤发生及发展中起重要作用，并与肿瘤血管新生密切相关，本文就SDF-1及其受体CXCR4，SDF-1／CXCR4轴在白血病细胞中的表达，SDF-1／CXCR4轴与白血病血管新生的关系，抗SDF-1／CXCR4抑制剂在血管新生治疗中的应用的研究进展加以综述。
|
| 关 键 词： | 白血病 SDF-1/CXCR4轴 血管新生 |
| 文章编号： | 1009-2137(2008)02-0447-05 |
| 修稿时间： | 2007年3月20日 |
Advance of Research on SDF-1/CXCR4 Axis and Angiogenesis in Leukemia——Review |
| |
| BAO Cui-Hua,HE Qi-Tu.Advance of Research on SDF-1/CXCR4 Axis and Angiogenesis in Leukemia——Review[J].Journal of Experimental Hematology,2008,16(2):447-451. |
| |
| Authors: | BAO Cui-Hua HE Qi-Tu |
| |
| Institution: | Department of Hematology, The First Affiliated Hospital, Baotou Medical College, Baotou 014010, Inner Mongolia Autonomous Region, China. |
| |
| Abstract: | The study on biological effects of SDF-1/CXCR4 axis composed of stromal cell derived factor-1 (SDF-1) and its receptor CXCR4 is progressing rapidly in the recent years. The SDF-1/CXCR4 axis plays an important role in occurrence and development of tumors and closely correlate with angiogenesis of tumors. This review focuses the progress of study on SDF-1/CXCR4 axis and angiogenesis in leukemia including SDF-1/ and its receptor CXCR4, the expression of SDF-1/CXCR4 axis in leukemic cells, the mechanism of relation between SDF-1/CXCR4 axis and angiogenesis in leukemia, the application of inhibitors against SDF-1/CXCR4 in treatment of angiogenesis and so on. |
| |
| Keywords: | leukemia SDF-1/CXCR axis angiogenesis |
| 本文献已被 维普 万方数据 等数据库收录！ |
