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Intravenous immunoglobulin as first treatment in diabetics with concomitant distal symmetric axonal polyneuropathy and CIDP |
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| Authors: | Cocito Dario Ciaramitaro Palma Isoardo Gianluca Barbero Pierangelo Migliaretti Giuseppe Pipieri Antonio Proto Giuliana Quadri Roberto Bergamasco Bruno Durelli Luca |
| Affiliation: | (1) U. O. A. D. U. Neurologia I, Dipartimento di Neuroscienze, Università di Torino, Via Cherasco 15, 10126 Torino, Italy. Tel.: +39-11/6 33 54 36, Fax: +39-11/6 96 34 87, E-Mail: dariococito@yahoo.it, IT;(2) Unità di Statistica, Dipartimento di Sanità pubblica e Microbiologia, Università di Torino, Via Santena 5, 10126 Torino, Italy, IT;(3) Dipartimento di Neuroscienze, Università di Catania, IT;(4) U. O. A. D. U. Medicina I, Dipartimento di Medicina Interna, Università di Torino, IT |
| Abstract: | The authors investigated the impact of IVIg as first line treatment of diabetic patients suffering from chronic inflammatory demyelinating polyneuropathy (CIDP) concomitant with distal symmetric axonal polyneuropathy. Nine patients with these clinical and electrophysiological features were treated with IVIg (0.4 g/Kg/day for 5 days). Clinical and electrophysiological evaluations were performed before and after treatment. Following IVIg treatment there was no significant improvement in clinical deficit. However, there was a significant and persistent decrease in the Rankin scale score and an improvement in the demyelinating feature on nerve conduction studies. Our findings suggest that IVIg had small but detectable beneficial effects on diabetic patients with CIDP and a high degree of axonal damage. Received: 10 August 2001, Received in revised form: 5 November 2001, Accepted: 7 November 2001 |
| Keywords: | polyneuropathy chronic inflammatory demyelinating polyneuropathy diabetes intravenous immunoglobulin |
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