胸腺五肽联合干扰素治疗复发性尖锐湿疣疗效分析及对T细胞亚群影响的研究

目的：探讨胸腺五肽治疗复发性尖锐湿疣的临床疗效及对T淋巴细胞亚群水平的影响。方法：选取皮肤性病科门诊的复发性尖锐湿疣患者74名，随机分成治疗组与对照组，用微波将疣体彻底去除，并予以肌注干扰素（100万u/d）治疗，治疗组加用胸腺五肽（1mg/d）肌注，疗程30d。两组均于治疗前及治疗结束3个月后用流式细胞术检测外周血T淋巴细胞亚群含量。结果：治疗组总有效率为86.8％，对照组总有效率为63.9％，两组差异有统计学意义（P＜0.05）。治疗组治疗后CD3＋T淋巴细胞、CD4＋T淋巴细胞及CD4＋/CD8＋T淋巴细胞比值上升，CD8＋T淋巴细胞降低，与治疗前比较差异均有统计学意义（P＜0.05）；对照组治疗后CD3＋T淋巴细胞、CD4＋T淋巴细胞及CD4＋/CD8＋T淋巴细胞比值较治疗前有所上升，CD8＋T淋巴细胞有所下降，但差异均无统计学意义（P＞0.05）；治疗后比较，治疗组CD3＋T淋巴细胞、CD4＋T淋巴细胞及CD4＋/CD8＋T淋巴细胞比值均较对照组高（P＜0.05），CD8＋T淋巴细胞较对照组低（P＜0.05），差异均有统计学意义。结论：胸腺五肽能调节T淋巴细胞亚型的动态平衡，提升复发性尖锐湿疣患者T淋巴细胞免疫功能，临床效果显著，且无明显不良反应，安全性好，值得临床推广应用。

Efficacy of thymopentin-5 combined with interferon and its influence on T cell subsets in patients with re-current condyloma acuminatum

To explore the clinical therapeutic effect and the change of T lymphocyte subsets in peripheral blood of patients with recurrent conduloma acuminatum after using thymopentin-5 .Methods：74 pa-tients with recurrent condyloma acuminatum in our hospital were randomly divided into treatment group and control group.All patients were treated by microwave burning under local anesthesia.Then,the patients in treatment group were injected in muscle with Interfeorn （1 000 000 u/d）and thymopentin-5 （1 mg/d）,but those in control group were treated with Interfeorn only,both for 30 days.The level of T lymphocyte subsets in peripheral blood were ex-amined by flow cytometry before therapy and 3 month after treatment for both groups.Results：The total effective rate of treatment group was 86.8%,while the total effective rate of the control group was 63.9%,with statistically significant difference （P〈0.05）.The CD3 ＋T cells,CD4 ＋T cells and the ratio of CD4 ＋/CD8 ＋after treatment in the treatment group were all significantly higher than that before treatment （all P〈0.05）;while the CD8＋T cells were lower after treatment （P〈0.05 ）.The CD3 ＋T cells,CD4 ＋T cells,CD8 ＋T cells and the ratio of CD4 ＋/CD8 ＋in the control group showed no statistical difference before and after treatment （all P〉0.05）;Compared with the control group after treatment,the CD3 ＋T cells,CD4 ＋T cells and the ratio of CD4 ＋/CD8 ＋in the treatment group were all higher,while the CD8＋T cells were lower in the treatment group （P〈0.05）.Conclusion：Thymo-pentin-5 combined with Interferon in treating recurrent condyloma acuminatum has significantly clinical efficacy, and thymopentin-5 can keep the dynamic balance of T lymphocyte subsets,enhance the immune function of T lym-phocytes in patients with recurrent condyloma acuminatum,without obvious adverse effect.Thymopentin-5 is an i-deal,reliable immune enhancer,and it is safe to be used clinically and worthy to be popularized.