糖肾灵治疗糖尿病肾病30例临床观察

目的：寻求延缓糖尿病肾病肾功能恶化的中西医结合治疗的有效方法。方法：将60例病例随机分为两组。两组性别、年龄、24小时尿蛋白定量和血肌酐经统计学处理差异无显著性意义。经饮食、运动及降糖药物治疗，有效严格地控制血糖，使空腹血糖〈7．0mmol／L，糖基化血红蛋白〈8％。对照组用洛汀新治疗，治疗组用糖肾灵＋洛汀新治疗，疗程2个月，检测治疗前后24小时尿蛋白定量、Scr及BUN水平。结果：两组治疗前后Scr水平差异均无显著性意义，P〉0．05；两组治疗后尿蛋白定量下降，与治疗前比较，P均〈0．05。治疗组降低尿蛋白的疗效又明显优于对照组，P〈0．05。结论：中西医结合治疗在延缓糖尿病肾病肾功能恶化、改善患者生活质量方面优于单用西药治疗。

Clinical Observation of Treating 30 Cases of Diabetic Nephropathy with Tangshenling

Objective:To explore the effective therapeutic method of traditional Chinese medicine combined with western medicine to postpone renal function deterioration of diabetic nephropathy.Methods:60 cases of diabetic nephropathy were randomly divided into the treatment group and the contrast group.Two groups had no significant difference by statistics in age,sex,urine protein/24h and serum createnine.By control of die,sport and hypoglycemic drug,blood glucose was strictly controlled with fasting plasms glucose(FPG) <7.0mmol/L and glycolsylated hemoglobin < 8%.The contrast group was treated by Lotensin and the treatment group by Tangshenlin and Lotension for two months.Urine protein/24h,serum creatinine(Scr) and blood uria nitrogen(BUN) was detected before and after treatment.Results:The level of Scr in two groups had no significant difference(P>0.05) and the decrease of BUN in two groups had statistical meaning (P<0.05).The decrease of BUN in the treatment group was much than that in the contrast group(P<0.05).The parameter of hemorheology and trauma of nerve function were obviously improved(P<0.01).Conclusion:Treating with traditional Chinese medicine combined with western medicine has better effect than only western medicine in postponing renal function deterioration of diabetic nephropathy and improving life quantity.