丙型肝炎病毒RNA阳性的肾移植受者免疫抑制剂的应用

目的 探讨肾移植术后发生丙型肝炎的受者合理的免疫抑制方案。方法 将２５例丙型肝炎病毒ＲＮＡ（ＨＣＶ ＲＮＡ）阳性的患者分为３组，分别给予硫唑嘌呤（Ａｚａ）＋环孢素Ａ（ＣｓＡ）＋泼尼松（Ｒｒｅｄ）（Ａｚａ组）、霉酚酸酯（ＭＭＦ）＋ＣｓＡ＋Ｐｒｅｄ（ＭＭＦ组）和ＭＭＦ＋Ｐｒｅｄ，并以３０例ＨＣＶ ＲＮＡ阴性受者为对照。结果Ａｚａ组和８／１２的患者肝功能发生异常；ＭＭＦ组有２／８的患者肝功能发生异常；Ｍ

The use of the immunosuppressives for the patients with HCV after renal transplantation

Objective To study the use of immunosuppressives for the patients with virus C hepatitis (HCV) after renal transplantation. Methods Twenty five cases of HCV RNA( ) and 30 cases of HCV RNA(-) as control group were analyzed. All patients were divided into the Aza group ( n =12), MMF group ( n =8) and MP (MMF Pred) group ( n =5). Results Eight cases revealed abnormal liver function in the Aza group and 2 in MMF group. After stopping the use of CsA and Aza, the liver function all revealed good outcome in the MP group . During one week 30 cases of HCV RNA(-) recovered due to the readjustment of the dosage of immunosuppressives (CsA, Aza) in the control group. Conclusions The therapy of MMF CsA Pred is necessary for the patients with HCV RNA( ) and the function of the renal and liver can be stabilized by MMF.