| 西咪替丁对小鼠骨髓细胞的抑制作用 |
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| 引用本文： | 谢蜀生,张文仁.西咪替丁对小鼠骨髓细胞的抑制作用[J].现代免疫学,1989,9(3):129-132. |
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| 作者姓名： | 谢蜀生 张文仁 |
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| 作者单位： | 北京医科大学免疫学教研室
(谢蜀生，张文仁)，北京医科大学免疫学教研室(龙振洲) |
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| 摘 要： | 本文用小鼠骨髓移植模型研究了西咪替丁对骨髓细胞的毒性作用.结果表明,在100mg/kg/天的剂量下,连续用药50天,免疫重建小鼠脾细胞对Con A和LPS的增殖反应明显受到抑制;对TNP-Ba特异的PFC反应以及对BSA诱导的DTH反应也较对照组明显降低。CFU-S的检测结果表明,西咪替丁对小鼠造血干细胞有明显抑制作用。
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| 关 键 词： | 西咪替丁 造血干细胞 骨髓细胞 |
INHIBITORY EFFECT OF CIMETIDINE ONMICE BONE MARROW CELLS |
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| Abstract: | In this report, a model of syngeneic bone marrow transplantation was used to investigate the toxic effect of Cimetidine on bone marrow cells. After 50days consecut-tive days administration of Cimetidine at the dose of 100mg/kg/day,the mitogenic response to ConA and LPS, the PFC response to TNP-Ba and the DTH induced by BSA were much inhibited in drug-receiving mice as compared with control mice. The results of CFU-s assay indicated that Cimetidine may directly inhibit the pluripotential stem cells of bone marrow. |
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