非小细胞肺癌患者血浆纤维蛋白原检测的临床意义

目的探讨非小细胞肺癌(NSCLC)患者血浆纤维蛋白原水平与肺癌临床病理特征关系及预后的相关性。方法对55例NSCLC患者及20例健康人的血浆纤维蛋白原分别进行测定。结果NSCLC患者血浆纤维蛋白原水平显著高于健康对照组(P<0.01),肺癌患者血浆纤维蛋白原水平与患者的病理类型、TNM分期之间无明显关系。NSCLC患者血浆纤维蛋白原水平与其生存期之间有显著的负相关(r=-0.37,P<0.01)。结论NSCLC患者存在血浆纤维蛋白原水平增高,血液存在高凝状态;血浆纤维蛋白原水平与患者的生存期呈负相关,血浆纤维蛋白原是反映NSCLC患者预后的重要指标。

Clinical significance of plasma fibrinogen level detection in non-small cell lung cancer patients

Objective To study the relationship between plasma fibrinogen level on pathophysiological characteristics and prognosis in patients with non-small cell lung cancer.Methods The plasma levels of fibrinogen were detected in fifty-five patients with non-small cell lung cancer and twenty normal controls.Results The plasma levels of fibrinogen in patients with non-small cell lung cancer were significantly higher than those of normal controls(P<0.001).The plasma levels of fibrinogen in patients with non-small cell lung cancer were not related to histological classification or P-TNM stages.The plasma levels of fibrinogen in patients with non-small cell lung cancer were negatively correlated to the survival span(r=-0.37,P<0.01).Conclusions Elevation of plasma levels of fibrinogen exists in patients with non-small cell lung cancer.The elevated plasma fibrinogen level may be associated with hypercoagulability state;the plasma levels of fibrinogen were negatively correlated to the survival span in patients with non-small cell lung cancer and they were important marker of prognosis of patients with non-small cell lung cancer.