Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice |
| |
Authors: | Parker Alexander Garcia Peraza Gianni Goulart Sena Janaina Silva Eli Sinnott Soares Maria Cristina Flores Vaz Marta Regina Cezar Furlong Eliana Badiale Muccillo-Baisch Ana Luiza |
| |
Institution: | Programa de Pós-Gradua??o em Enfermagem, Funda??o Universidade Federal do Rio Grande, Rio Grande, Brazil. |
| |
Abstract: | The infusion of Brugmansia suaveolens, popularly known as trombeteira or cartucheira, has been used to treat pain in Brazil. The present study was conducted to test for its antinociceptive effects using the abdominal-writhing, formalin, tail-flick, and hot-plate tests in mice. The aqueous extract from B. suaveolens flowers administered intraperitoneally at doses of 100 and 300 mg/kg body weight significantly inhibited acetic acid-induced abdominal constrictions. An increase in hot-plate latency was also observed in animals receiving both doses (100 and 300 mg/kg). In the formalin test, both doses from the aqueous extract inhibited the first (0-5 min) and second phase (20-25 min). Tail-flick assays demonstrated that treatment of animals with plant extract induced attenuation of the response. These results suggest that the aqueous extract from B. suaveolens flowers produced antinociceptive effects, as demonstrated in the experimental models of nociception in mice. This supports popular medicinal uses of this plant as an analgesic. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|