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Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimus |
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| Authors: | Okan Gokhan Yaylaci Serpil Peker Onder Kaymakoglu Sabahattin Saruc Murat |
| Affiliation: | 1. Dermatology Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey 2. Emergency Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey 3. Pathology Department, Aeibadem Hospital, Bakirkoy 34140, Turkey 4. Division of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty, Istanbul 34140, Turkey 5. Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul 34140, Turkey |
| Abstract: | Stevens-Johnson syndrome (SJS) is a serious and potentially life-threatening disease. Vanishing bile duct syndrome (VBDS) is a rare cause of progressive cholestasis. Both syndromes are mostly related with drugs. We report a case of a patient withciprofloxacin-induced SJS and acute onset of VBDS,and reviewed the related literature. It is the first case of ciprofloxacin-induced VBDS successfully treatedwith tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management. |
| Keywords: | Stevens-Johnson syndrome Vanishing bile duct syndrome Ciprofloxacin Tacrolimus |
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