青少年肥胖与某单核苷酸多态性的相关性研究

目的探讨我国青少年肥胖与单核苷酸多态性rs7566605的相关性,为进一步研究rs7566605在我国人群中的发生情况提供参考。方法在北京市东城区选择919名14-17岁初中生,进行身体测量和rs7566605基因型鉴定。结果919名青少年rs7566605突变率(G>C)为35.9%,与欧美人接近。体重正常、超重和肥胖组基因型及等位基因频率差异无统计学意义(P>0.05)。进一步比较体重正常和重度肥胖组[体质量指数(BMI)≥30]发现,重度肥胖青少年CC基因型频率明显高于体重正常组,分别为18.5%,10.3%,CC基因型携带者比GC/CC基因型更容易发生重度肥胖(OR=1.101,P<0.05)。CC基因型携带者的BMI平均比GG/GC基因型者高0.88 kg/m2(P<0.05)。结论单核苷酸多态性rs7566605与我国青少年重度肥胖发生有关,CC基因型携带者发生重度肥胖的危险性更大。

Correlation Study on Obesity and A Single Nucleotide Polymorphism in Adolescents

Objective To explore the relationships between obesity and the single nucleotide polymorphism rs7566605 in Chinese adolescents,and to provide reference for the research on the incidence of rs7566605 in Chinese people.Methods Altogether 919 middle-school students were selected from Dongcheng District,Beijing.Physical examination and the polymorphism analysis were performed for all subjects.Results The frequency of rs7566605 C-allele was 35.9%,similar to that of European and Americans.The differences of genotype and frequencies were not statistically significant among the normal-weight,overweight and obesity groups(P>0.05).However,the frequency of CC genotype of the extremely obese students was significantly higher than that of the normal-weight group,which was 18.5% and 10.3% respectively.The carrier of CC genotype was more likely to become extremely obese than the GG/GC carrier(OR=1.101,P<0.05).The average BMI of CC carriers was 0.88 kg/m~2 higher than that of GG/GC people(P<0.05).Conclusion The single nucleotide polymorphism rs7566605 is associated with extremely obesity in Chinese adolescents.The carrier of CC genotype has higher risk to become extremely obese.