银杏达莫治疗急性特发性面神经麻痹随机对照研究

目的：评价银杏达莫治疗急性特发性面神经麻痹的疗效。方法：62例急性特发性面神经麻痹患者随机分为银杏达莫组31例及对照组31例，分别应用银杏达莫25mL及丹参注射液20mL静脉滴注，每天1次，连续治疗14d，两组均同时使用相同剂量的泼尼松、抗病毒药及维生素B族治疗。治疗后1、3和4周采用House—Brackmann分级法进行疗效评估。结果：治疗后3周银杏达莫组患者痊愈率为48．38％（15／31），改善率为25．81％（8／31），总有效率74．19％；丹参组患者痊愈率为25．81％（8／31），改善率为16，13％（5／31），总有效率41．94％。治疗后4周，银杏达莫组痊愈率为74．19％（23／31），改善率为19．35％（6／31），总有效率93．55％；丹参组痊愈率为45．16％（14／31），改善率为22．58％（7／31），总有效率67．74％。两组间疗效差异有统计学意义（P〈0．05）。结论：银杏达莫治疗急性特发性面神经麻痹的疗效好于丹参。

The Control Study on Yinxingdamo Injection in the Treatment of Acute Facial Palsy

Aim:To evaluate the effect of Yinxingdamo injection on the acute idiopathic facial palsy. Methods:62 patients diagnosed as acute idiopathic facial palsy were randomly assigned to Yinxingdamo injection group (n=31) used Yinxingdamo 25 mL per day , and comparison group (n=31) used Danshen 20 mL per day separately for fourteen days. The same dose of prednisone, antivirus drug and vitamin B were used in each group. House-Brackmann facial nerve grading system was used to evaluate the outcome of treatments at the time of 1 week, 3 weeks and 4 weeks. Results:Fifteen patients(48.38 %) recovered completely in Yinxingdamo group comparing with 8 patients (25.80 %) in Danshen group (P <0.05) after 3 weeks treatment, and 23 patients (74.19 %) recovered completely in Yinxingdamo group comparing with 14 patients (45.16 %) in Danshen group ( P<0.05) at the end of 4 weeks. Conclusion :Yinxingdamo injection is superior to Danshen injection in treating acute idiopathic facial palsy.