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Evaluation of HER2 status: For the treatment of metastatic breast cancers by humanized anti-HER2 monoclonal antibody (trastuzumab) (Pathological committee for optimal use of trastuzumab) |
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| Authors: | Shinobu Umemura Goi Sakamoto Hironobu Sasano Hitoshi Tsuda Futoshi Akiyama Masafumi Kurosumi Yutaka Tokuda Toru Watanabe Masakazu Toi Tadashi Hasegawa R. Yoshiyuki Osamura |
| Affiliation: | Department of Pathology, Tokai University School of Medicine, Isehara, 259-1193, Japan. |
| Abstract: | For the treatment of patients with metastatic breast cancer by humanized anti- human epidermal growth factor receptor type 2 (HER2) antibody (trastuzumab), it is important to evaluate HER2 status adequately. "A guideline for HER2 testing" and "HER2 atlas" produced by the "Pathological committee for optimal use of trastuzumab" are introduced in this report. Appropriate evaluations of biological markers are essential for targeting therapy. |
| Keywords: | Breast cancer HER2 Trastuzumab Guideline Immunohistochemisfry FISH |
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