| p21和p27基因多态性与肿瘤的相关性 |
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| 引用本文： | 李作生,李保庆. p21和p27基因多态性与肿瘤的相关性[J]. 国际遗传学杂志, 2006, 29(4): 317-320. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| 作者姓名： | 李作生 李保庆 |
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| 作者单位： | 1. 063000,唐山市人民医院
2. 050011,石家庄,河北医科大学附属第四医院胸外科 |
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| 摘 要： | 做为细胞周期依赖性蛋白激酶抑制剂，p21和p27被认为是侯选的抑癌基因，在细胞周期的调控中发挥重要作用。p21和p27基因的突变或多态性可能与人类多种肿瘤的发生发展有关。研究该二基因的多态性可能有助于判断肿瘤的发病风险、临床特征以及预后。
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| 关 键 词： | p21；p27；基因多态性；肿瘤 |
| 收稿时间： | 2005-04-28 |
| 修稿时间： | 2005-04-28 |
Correlation of Gene Polymorphism of p21 and p27 with Tumor |
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| LI Zuo-sheng,LI Bao-qing. Correlation of Gene Polymorphism of p21 and p27 with Tumor[J]. International JOurnal of Genetics, 2006, 29(4): 317-320. DOI: 10.3760/cma.j.issn.1673-4386.2008.06.002 |
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| Authors: | LI Zuo-sheng LI Bao-qing |
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| Abstract: | As the cyclin-dependent kinase inhibitors,p21 gene and p27 gene are regarded as candi- dates of tumor suppressive gene,and have important functions in cell cycle control.Mutation or polymorphisms of these two genes may connect with many human tumors.It's maybe helpful to estimate the risk of developing tumor and indicate the clinical characteristic and prognosis of tumor by studying their polymorphisms. |
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| Keywords: | p21 p27 Polymorphism Tumor |
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