| 调节性T细胞、调节性B细胞与支气管哮喘 |
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| 引用本文： | 蒋胜华,程兆忠. 调节性T细胞、调节性B细胞与支气管哮喘[J]. 国际呼吸杂志, 2016, 0(16): 1252-1255. DOI: 10.3760/cma.j.issn.1673-436X.2016.16.013 |
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| 作者姓名： | 蒋胜华 程兆忠 |
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| 作者单位： | 1. 272019,济宁医学院附属医院呼吸内科;2. 266101,青岛大学附属医院呼吸内科 |
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| 摘 要： | 支气管哮喘(简称哮喘)是一种由多种细胞及细胞组分参与的气道慢性炎症性疾病,目前经典的Th1/Th2理论并不能完全解释哮喘的免疫失衡.调节性T细胞(Tregs)和调节性B细胞(Bregs)是一类具有免疫抑制作用的淋巴细胞亚群,通过多种免疫调节通路调控免疫应答.本文就Tregs、Bregs的生物学特性与哮喘发病机制及其免疫治疗最新研究进展作一综述.
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| 关 键 词： | 调节性T细胞 调节性B细胞 哮喘 |
Reulatory T cells and regulatory B cells in bronchial asthma |
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| Abstract: | Bronchial asthma(asthma) is a chronic inflammatory of the airways in which many inflammatory cells and mediators participate.The classical theory Th1/Th2 imbalance has failed to explain those disorders adequately.Regulatory T cells (Tregs) and regulatory B cells (Bregs) are immunosuppressive lymphocyte subpopulation cells,using several distinct suppressive mechanisms.With many advances regarding the biological processes of Tregs and Bregs,the knowledge of those cells and their clinical and immunological significance in asthma are described in this review. |
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| Keywords: | Regulatory T cells Regulatory B cells Asthma |
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