健康人群网织红细胞参数及与成熟红细胞参数的比较研究

目的探讨网织红细胞的某些参数与成熟红细胞相应参数间的关系。方法应用西门子Advia 2120血细胞分析仪对112例男性和110例女性健康体检者进行多项网织红细胞参数测定,确认参考范围,并与成熟红细胞5项相应的参数进行比对分析。结果纳入研究者中,女性的网织红细胞百分比(Retic%)、网织红细胞绝对值(Retic#)、网织红细胞平均血红蛋白含量(CHr)、网织红细胞平均体积(MCVr)的参考范围分别为0.45%~1.76%、(22~86)×109/L、30.1~36.4pg、99.5~113.7fL;男性的这4项参数的参考范围分别为0.54%~1.93%、(29~104)×109/L、32.6~36.6pg、97.6~112.7fL。网织红细胞计数男性高于女性,差异有统计学意义(P0.05)。MCVr明显大于成熟红细胞平均体积,且女性略高于男性;CHr明显高于成熟红细胞的平均血红蛋白量,而体积较大的网织红细胞内的平均血红蛋白浓度则低于成熟红细胞的平均血红蛋白浓度;网织红细胞体积分布宽度低于成熟红细胞体积分布宽度;成熟红细胞内血红蛋白含量的均一性则比网织红细胞内血红蛋白含量均一性好。结论建立了网织红细胞一些应用较少的参数的参考范围并与红细胞的相应参数进行了分析。

Reticulocyte parameters of normal human and its relationship with mature erythrocyte parameters

Objective To investigate the relationship between the parameters of the red blood cells and the corresponding param‐eters of mature red blood cells .Methods Blood samples of 112 healthy males and 110 healthy females were tested for these reticu‐locyte parameters by using Siemens Advia2120 hematology analyzer .Reference intervals were established .Comparisons between these reticulocyte parameters and the corresponding parameters of mature erythrocytes were drawn .Results Reference intervals for the healthy group recruited in this study were determined as follows .Females ,percentage of reticulocyte (Retic% ):0 .45% ~1 .76% ,absolute reticulocyte number(Retic#):(22~86)× 109/L ,mean corpuscular hemoglobin content of reticulocyte(CHr):30 . 1~36 .4 pg ,mean corpuscular volume of reticulocyte(MCVr):99 .5~113 .7 fL .Male ,Retic% :0 .54% ~1 .93% ,Retic# :(29~104)× 109/L ,CHr :32 .6~36 .6 pg ,MCVr :97 .6~112 .7 fL .The absolute reticulocyte of male is significantly higher than that of female;MCVr was significantly larger than mean corpuscular volume of mature erythrocytes ,which was also slightly larger in male than that in female;CHr was significantly higher than mean corpuscular hemoglobin of mature erythrocytes while mean corpuscular hemoglobin concentration of large reticulocytes was lower than that of mature erythrocytes;red blood cell volume distribution width of reticulocytes was lower than that of mature erythrocytes;the hemoglobin content distribution width of mature erythrocytes has a higher uniformity compared with reticulocytes .Conclusion The reference ranges of not commonly used parameters of reticulocytes were established ,and were compared with the corresponding parameters of red blood cells .