不同糖代谢状态患者与血清IL-6、IL-18水平的相关性研究

目的探讨不同糖代谢状态与白细胞介素(IL)-6、IL-18水平的关系。方法分别选取糖尿病前期组、2型糖尿病(T2DM)组和健康对照(NC)组患者各30例,采集空腹静脉血测定空腹血糖(FPG)、三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)等指标,采用酶联免疫法测定静脉血清中IL-6、IL-18水平。结果糖尿病前期组和T2DM组的IL-6、IL-18水平较NC组明显升高,差异有统计学意义(P0.01)。IL-6水平与FPG、TG、IL-18呈正相关,IL-18水平与FPG、TG、IL-6呈正相关(P0.05),IL-6和IL-18均与HDL-C呈负相关(P0.05),但与TC、LDL-C无明显相关性(P0.05)。结论 IL-6和IL-18参与了T2DM的发病机制,其血清水平可作为糖尿病前期人群筛查和逆转干预效果评价的指标。

Study on correlation between patients with different glucose metabolism status and levels of serum IL-6 and IL-18

Objective To investigate the relation between different glucose metabolism status and the IL‐6 and IL‐18 levels . Methods The pre‐diabetes group ,type 2 diabetes mellitus(T2DM) group and healthy control group(NC) were selected with 30 ca‐ses in each group .Fasting venous blood was collected for detecting fasting plasma glucose (FPG) ,triglyceride(TG) ,total cholester‐ol (TC) ,low‐density lipoprotein‐cholesterol (LDL‐C) and high‐density lipoprotein‐cholesterol (HDL‐C) levels .Serum IL‐6 and IL‐18 levels were measured by adopting the enzyme‐linked immunosorbent assay(ELISA) .Results The IL‐6 and IL‐18 levels in pre‐diabetes and T2DM groups were significant increased compared with those in the NC group ,the difference was statistically signifi‐cant (P<0 .01) .The IL‐6 level was positively correlated with FPG ,TG and IL‐18(P<0 .05) ,the IL‐18 level was positively correla‐ted with FPG ,TG and IL‐6(P<0 .05) .But IL‐6 and IL‐18 were negatively correlated with HDL‐C(P<0 .05) ,however ,had no cor‐relation with TC and LDL‐C (P>0 .05) .Conclusion IL‐6 and IL‐8 participated in the pathogenesis of T2DM ,their serum concen‐trations can be used as the evaluation indexes of pre‐diabetes screening and reverse intervention effect .