肺动脉高压治疗过程中抗凝药物应用的研究进展

肺动脉高压是一组以肺血管阻力持续增加为特征的临床综合征，其发病机制复杂，预后差。有研究表明原位血栓形成及凝血功能紊乱在肺动脉高压的发病机制中起着重要作用，是肺动脉高压发生发展的重要机制之一。但目前关于抗凝药物在肺动脉高压中的应用始终无统一的结论，本文就肺动脉高压治疗过程中应用抗凝药物的病理学和生理学基础及目前抗凝药物在肺动脉高压应用情况及最新进展展开综述。

Advances in the application of anticoagulant drugs during the treatment of pulmonary hypertension

Pulmonary hypertension is a group of clinical syndrome characterized by increased pulmonary vascular resistance,its pathogenesis is complex and prognosis is poor.Studies have shown that situ thrombosis and blood coagulation dysfunction play an important role in the pathogenesis of pulmonary hypertension,both of them are weighted mechanisms of occurrence and development of pulmonary hypertension.However,the application of anticoagulant drugs in pulmonary hypertension has not been unified conclusion yet.In this article,we are going to expound pathological and physiological basis in application of anticoagulant drugs in pulmonary hypertension treatment,then we will review anticoagulant drugs currently in pulmonary hypertension application and the latest progress.