| 间歇低氧与内质网应激关系的研究进展 |
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| 引用本文： | 杜娟,顾晨鹃,李敏. 间歇低氧与内质网应激关系的研究进展[J]. 国际呼吸杂志, 2016, 0(12): 952-955. DOI: 10.3760/cma.j.issn.1673-436X.2016.12.015 |
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| 作者姓名： | 杜娟 顾晨鹃 李敏 |
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| 作者单位： | 200025,上海交通大学医学院附属瑞金医院呼吸内科 |
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| 基金项目： | 国家自然科学基金委员会青年科学基金项目资助(81400065),中国睡眠研究会青年科研基金项目(2014-05),上海市科委自然科学基金基础重点项目(11JC1411302)Fund program:Grants from the National Natural Science Foundation of China(81400065),Chinese Sleep Research Society Youth Research Fund Project(2014-05),Shanghai Municipal Natural Science Foundation(11JC1411302) |
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| 摘 要： | 内质网是蛋白质折叠和转运的重要场所,机体受到多种刺激可引起细胞内一系列反应,称为内质网应激(ERS)。OSAHS特征性的间歇低氧可引起 ERS,而 ERS在 OSAHS造成多系统损害中发挥的作用受到越来越多的关注,本文就间歇低氧与 ERS相互关系作一综述。
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| 关 键 词： | 间歇低氧 内质网应激 |
Research progress in the relationship between intermittent hypoxia and endoplasmic reticulum stress |
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| Abstract: | The endoplasmic reticulum (ER) is the major site in the cell for protein folding and trafficking.When triggered by many stress,cells launch a serious of response called endoplasmic reticulum stress (ERS).Obstructive sleep apnea-hypopnea syndrome (OSAHS) characteristic intermittent hypoxia can induce ERS.Recently the function of ERS in multisystem damage caused by OSAHS attract more and more attention.In this article,we will review the association of intermittent hypoxia and ERS. |
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| Keywords: | Intermittent hypoxia Endoplasmic reticulum stress |
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