泛耐药铜绿假单胞菌的感染现状及危险因素分析

目的探讨医院内泛耐药铜绿假单胞菌(PDRPA)的感染现状及其危险因素,为临床控制PDRPA感染提供依据。方法对该院2012年3月至2014年2月期间的铜绿假单胞菌进行院内感染监测,回顾性分析相应病例的临床资料,分析PDRPA感染的危险因素。结果 PDRPA主要分布于重症医学科和神经外科,以痰液为主,分别占泛耐药菌株标本来源的59.5%和31.0%;年龄、住院时间、使用抗菌药物时间、使用碳青霉烯类、使用头孢菌素类、使用喹诺酮类、糖尿病、冠心病、深静脉插管、气管插管、使用呼吸机、鼻饲胃管与PDRPA感染明显相关(P0.05),而与肿瘤、使用氨基糖苷类、混合感染无明显相关性(P0.05)。结论年龄、住院时间、使用抗菌药物时间、使用碳青霉烯类、使用头孢菌素类、使用喹诺酮类、糖尿病、冠心病、深静脉插管、气管插管、使用呼吸机、鼻饲胃管是PDRPA感染的危险因素,因此,控制糖尿病、冠心病,合理使用抗菌药物,减少侵袭性操作是预防和控制PDRPA院内感染的关键。

Infection status of Pan resistant Pseudomonas aeruginosa and risk factor analysis

Objective To study status and risk factors of nosocomial infection of Pseudomonas aeruginosa in hospital ,provided a basis to clinical control infected of PDRPA .Methods Monitoring of nosocomial infection of Pseudomonas aeruginosa from Februar‐y 2014 to March 2012 in our hospital ,retrospective analysis of the clinical data of the corresponding cases ,analysis of the risk fac‐tors for PDRPA infection .Results PDRPA was mainly distributed in the severe medicine department and department of Neurosur‐gery ,given priority to with sputum ,59 .5% and 31 .0% were the source of the pan resistant strains ,respectively ;Age ,duration of hospitalization ,use of antimicrobial drugs ,the use of carbapenems ,the use of cephalosporins ,quinolones ,diabetes ,coronary heart disease ,deep vein intubation ,endotracheal intubation ,ventilator ,nasogastric tube and PDRPA infection significantly correlated(P<0 .05) ,There was no significant correlation with tumor ,the use of amino glycosides and mixed infection(P>0 .05) .Conclusion Age ,duration of hospitalization ,use of antibacterial drugs ,the use of carbapenems ,the use of cephalosporins ,quinolones ,diabetes , coronary heart disease ,deep vein intubation ,endotracheal intubation ,ventilator ,nasogastric tube is a risk factor for PDRPA infec‐tion ,Control of diabetes ,coronary heart disease ,rational use of antimicrobial agents ,reduce the invasive operation is the key to pre‐vent and control nosocomial infection in PDRPA .