下呼吸道微生物菌群对宿主免疫的影响

随着细菌鉴定技术的发展,健康成年人下呼吸道存在常驻微生物菌群的观点逐渐受到认可.这类微生物菌群具有调节天然免疫和获得性免疫反应的作用.在呼吸道疾病如哮喘、COPD的发生发展过程中,宿主下呼吸道微生态环境发生改变,免疫状态也发生了改变,但两者之间的关系尚不明确.我们将围绕下呼吸道微生物菌群对宿主免疫系统的影响进行阐述,以探讨影响呼吸道疾病发生发展的因素.

The impact of lower respiratory tract microbiota on the host immune system

With the development of bacterial identification technology,we know that lower respiratory tract of healthy people is not sterile.The microbiota resident in human lower respiratory tract plays the role on the mature of host immune system,which has the ability to regulate the innate immune response and adaptive immune response.When respiratory diseases developed,such as asthma and chronic obstructive pulmonary disease,micro-ecological environment of host lower respiratory tract changed,and host immune status also changed,but their relationship is not clear.Here,we would state the impact of lower respiratory tract microbiota on the host immune system,especially on the development of respiratory disease.