糖尿病视网膜病变危险因素分析

目的分析糖尿病视网膜病变(DR)的危险因素,为DR的防治提供依据。方法100例2型糖尿病(T2DM)患者按有无DR分为糖尿病非视网膜病变组(NDR组)50例和糖尿病视网膜病变组(DR组)50例,检测其糖化血红蛋白(HbA1c)、空腹血糖(FBG)、血尿酸(UA)、C-反应蛋白(CRP)、同型半胱氨酸(HCY)、血镁、血脂、血压等,并进行组间比较,DR与各种影响因素间相关性检验用Logistic多因素逐步回归分析。结果DR组年龄、病程、收缩压(SBP)、HbA1c、CRP、HCY、UA、低密度脂蛋白-胆固醇(LDL-C)较NDR组明显升高(P<0.05)、血镁水平较NDR组明显减低(P<0.05)。Logistic分析显示年龄、病程、SBP、GHbA1c、CRP、HCY等6个变量是DR发生的独立危险因素。结论除血糖、血压和病程等因素外,血CRP、HCY、UA等的升高和血镁的降低可能也与DR的发生有关。

Analysis on relative risk factors of diabetic retinopathy

Objective To analyze related risk factors of diabetic retinopathy（DR） and provide the basis for the prevention and treatment of DR. Methods 100 cases of patients suffered from type 2 diabetes （T2DM） were di- vided into 50cases of diabetic non-retinopathy group （ NDR group） and 50 cases of diabetic retinopathy group （ DR group）. Glycosylated hemoglobin （ GHbA1 c） ,fasting blood sugar （FBG） ,uric acid（UA） , C-reactive protein（ CRP）, homocysteic acid （HCY） ,blood magnesium ,serum lipid and blood pressure were measured in all the patients. T-test and Logistic multiple factor gradual regressive analysis was used for the statistical analysis. Results The age, course of disease, systolic blood pressure （SBP）, GHbAIc, CRP, CY, UA,low density lipoprotein-cholesterol （LDL-C） of the DR group were significantly higher than those of the NDR group （ P 〈 0. 05 ）, the blood magnesium value signifi- cantly lower than that of the NDR group （ P 〈 0. 05 ）. Logistic analysis revealed that the six variances, such as age, course of disease, SBP, GHbA1 c, CRP and HCY, were the independent risk factors of DR. Conclusion The elevation of serum CRP, HCY, UA and as well as the decrease in blood magnesium may be related to the occurrence of DR except the blood sugar,blood pressure and couse of disease.