|
|||||
|
|
Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer |
|
| Authors: | Mark R Pickard Andrew R Green Ian O Ellis Carlos Caldas Vanessa L Hedge Mirna Mourtada-Maarabouni Gwyn T Williams |
| Affiliation: | (1) Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Huxley Building, ST5 5BG Keele, UK;(2) Division of Pathology, School of Molecular Medical Sciences, University of Nottingham and Nottingham University Hospitals, Derby Road, NG7 2UH Nottingham, UK;(3) Cancer Research UK Cambridge Research Institute and Department of Oncology, University of Cambridge, Hills Road, CB2 0RE Cambridge, UK |
| Abstract: | IntroductionProgrammed cell death through apoptosis plays an essential role in the hormone-regulated physiological turnover of mammary tissue. Failure of this active gene-dependent process is central both to the development of breast cancer and to the appearance of the therapy-resistant cancer cells that produce clinical relapse. Functional expression cloning in two independent laboratories has identified Finkel–Biskis–Reilly murine sarcoma virus-associated ubiquitously expressed gene (Fau) as a novel apoptosis regulator and candidate tumour suppressor. Fau modifies apoptosis-controller Bcl-G, which is also a key target for candidate oncoprotein maternal embryonic leucine zipper kinase (MELK). |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |