| 肝星状细胞及髓源性抑制细胞在肝移植免疫耐受中的作用 |
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| 引用本文： | 钱诗光. 肝星状细胞及髓源性抑制细胞在肝移植免疫耐受中的作用[J]. 中华移植杂志(电子版), 2010, 0(4): 32-34 |
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| 作者姓名： | 钱诗光 |
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| 作者单位： | Department;Immunology;Surgery;Cleveland;Clinic; |
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| 摘 要： | 肝作为一个免疫特惠器官,不同品系间的小鼠肝移植尽管MHC不配,也能够自发耐受。肝非实质细胞如肝星状细胞通过诱导髓源性抑制细胞在肝移植免疫耐受中发挥重要作用。髓源性抑制细胞是一类调节性细胞群,最早发现于癌症患者,具有较强的免疫调节作用。阐明肝星状细胞及髓源性抑制细胞在肝移植免疫耐受中的作用机制对于临床实践中诱导供体特异的移植免疫耐受具有重大意义。
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| 关 键 词： | 肝星状细胞 髓源性抑制细胞 肝移植 免疫耐受 |
Hepatic stellate cells and myeloid-derived suppressor cells in liver transplant immune tolerance |
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| QIAN Shi-guang. Hepatic stellate cells and myeloid-derived suppressor cells in liver transplant immune tolerance[J]. Chinese Journal of Transplanation(Electronic Version), 2010, 0(4): 32-34 |
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| Authors: | QIAN Shi-guang |
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| Affiliation: | QIAN Shi-guang.Department of Immunology and Surgery,the Cleveland Clinic,OH 44195,USA |
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| Abstract: | Liver is an immunologically privileged organ.The rejection of liver transplants is relativelyeasier to be overcome compared to other solid organ transplants.The orthotopic mouse liver allograftsacross the MHC mismatched barriers are accepted without requirement of immunosuppression.Non-parenchymal liver cells including hepatic stellate cells(HSC) play a key role in liver transplant immunetolerance via induction of myeloid-derived suppressor cells(MDSC),a type of regulatory cells that was first identified in... |
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| Keywords: | Hepatic stellate cells Myeloid-derived suppressor cells Liver transplantation Immune tolerance |
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