| 采用一步制粒法影响清开灵颗粒孔隙率因素的探讨 |
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| 引用本文： | 邢继芳. 采用一步制粒法影响清开灵颗粒孔隙率因素的探讨[J]. 黑龙江医药, 2007, 20(4): 344-345 |
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| 作者姓名： | 邢继芳 |
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| 作者单位： | 远达药业集团哈尔滨一洲制药有限公司,150086 |
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| 摘 要： | 目的:探讨一步制粒机中影响清开灵颗粒孔隙率的因素;方法:采用一步制粒法对影响孔隙的因素进行试验;结果:对孔隙率影响大小的顺序为供液速率＞排风频率＞进风温度,并在优选的条件下试验,发现润湿粘附剂的浓度与孔隙率成反比;结论:采用一步制粒技术可形成孔隙率大的颗粒,大大提高了药物的溶出速率.
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| 关 键 词： | 一步制粒 孔隙率 清开灵颗粒 工艺研究 |
| 文章编号： | 1006-2882（2007）04-344-02 |
| 修稿时间： | 2007-01-09 |
Study on the Factors of Influencing Qingkailing Granules Porosity with One-step-granulating |
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| Xing Jifang. Study on the Factors of Influencing Qingkailing Granules Porosity with One-step-granulating[J]. Heilongjiang Medicine, 2007, 20(4): 344-345 |
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| Authors: | Xing Jifang |
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| Abstract: | Objective: In order to discuss the factor of one - step - granulating's influence on the Qingkailing granules porosity. Methods:We had an experiment with one- step- granulating. Results: the sequence of influencing porosity is that the rate of supplying liquid > the frequency of obviating wind > the temperature of putting in wind, the chroma of wetting agent conglutination and porosity show inverse ratio under the test of handpicked condition.Conclusion:with one-step - granulating we could get the granules with much larger porosity to raise the rate of dissolution. |
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| Keywords: | one - step - granulating porosity Qinkailing granules research of arts and crafts |
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