茶油及茶多酚抗炎作用及其机制研究

目的观察茶油及茶多酚对角叉菜胶致大鼠足跖肿胀的模型抗炎作用及其机制。方法建立角叉菜胶致大鼠足跖肿胀的模型,将甘油、茶油、1%茶多酚、0.5%茶多酚、0.25%茶多酚及哈西奈德分别涂抹于大鼠右后足,比较各组药物抑制肿胀的程度,并测定炎症组织中前列腺素E2及丙二醛（M D A）的量,以及超氧化物歧化酶（SO D）活力。结果①建立角叉菜胶所致大鼠足趾肿胀的动物模型。②各组对角叉菜胶所致大鼠足趾肿胀度均有不同程度的抑制作用。其中茶油、0.5%茶多酚和0.25%茶多酚在炎症的后期,均能抑制肿胀。与阴性对照组比较,具有统计学意义（P〈0.05或P〈0.01）;1%茶多酚与哈西奈德具有类似的显著抑制肿胀效果。③哈西奈德和茶多酚,抑制了PG E2的产生,与甘油组比较,具有统计学意义（P〈0.05或P〈0.01）。茶多酚抑制PG E2的产生,作用呈剂量依赖性。④茶油、哈西奈德溶液、1%茶多酚组的SO D活力数值较高,与阴性对照组比较,具有统计学意义（P〈0.05或P〈0.01）。茶油、哈西奈德溶液、茶多酚3个剂量组（1%、0.5%和0.25%）的M D A量降低,与甘油对照组比较,具有统计学意义（P〈0.05或P〈0.01）。结论茶油及茶多酚对角叉菜胶致大鼠的原发性刺激性炎症有抑制作用。

The investigation of anti-inflammatory effect of tea oil and tea polyphenol

Objective To investigate the anti-inflammatory effects of tea oil and tea polyphenol in carrageenan-induced rat paw edema model.Methods Tea oil and different concentration of tea polyphenol was applied on the right swelling paw of rats induced by carrageenan.The swelling degree was compared in different groups.The level of prostaglandin E2 and malondialdehyde,and the activity of superioxide dismutase were measured.Results The swelling degree of rat paw was relieved by application of tea oil and tea polyphen...