| Cyclin D1、PCNA和C-erbB-2在乳房外Paget病中的表达及意义 |
| |
| 引用本文： | 万慧颖,徐敏燕,冉玉平.Cyclin D1、PCNA和C-erbB-2在乳房外Paget病中的表达及意义[J].皮肤病与性病,2011,33(6):317-319. |
| |
| 作者姓名： | 万慧颖 徐敏燕 冉玉平 |
| |
| 作者单位： | 1. 四川省医学科学院·四川省人民医院皮肤病性病研究所,四川成都,610031
2. 四川大学华西医院皮肤性病科,四川成都,610041 |
| |
| 基金项目： | 四川省卫生厅科研课题(编号060100) |
| |
| 摘 要： | 目的研究c7clin D1、PCNA和C—erbB-2在乳房外Paget病中的表达及意义。方法用免疫组织化学技术检测28例乳房外Paget病的石蜡包埋组织及12例正常皮肤组织中Cyclin D1、PCNA和C—erbB-2的表达。结果CyclinDI在乳厉外Paget病组织中阳性率（92．86％）高于正常皮肤对照组（8．33％），两者差异有统计学意义（P〈0．05）；PCNA在乳房外Paget病组织中阳性率（89．29％）显著高于正常皮肤对照组（16．67％），两者差异有统计学意义（P〈0．01）；C—erbB-2在乳房外Paget病组织中阳性率（96．43％）高于正常皮肤对照组（8．33％），两者差异有统计学意义（P〈0．05）。结论Cyclin D1、PCNA和C-erbB-2在乳房外Paget病组织中均呈高表达，其与乳房外Paget病的发生关系密切。
|
| 关 键 词： | Cyclin D1 PCNA C-erbB-2 乳房外Paget病 |
The expression and correlation analysis of Cyclin D_1,PCNA and C-erbB-2 in patients with extramammary Paget's disease |
| |
| WAN Hui-ying,XU Min-yan,RAN Yu-ping.The expression and correlation analysis of Cyclin D_1,PCNA and C-erbB-2 in patients with extramammary Paget's disease[J].Journal of Dermatology and Venereology,2011,33(6):317-319. |
| |
| Authors: | WAN Hui-ying XU Min-yan RAN Yu-ping |
| |
| Institution: | WAN Hui-ying1,XU Min-yan1,RAN Yu-ping2 (1.Institute of Dermatovenereology,Sichuan Provincial People's Hospital,Chengdu 610031,China,2.Department of Dermatovenereology,West China Hospital,Sichuan University,Chengdu 610041,China) |
| |
| Abstract: | Objective To investigate the expression and correlation analysis of Cyclin D1,PCNA and C-erbB-2 in patients with extramammary Paget's disease(EMPD).Methods The immunohistchemical staining was performed to detect the expression of Cyclin D1,PCNA and C-erbB-2 in the tissue specimens of 28 cases of EMPD and 12 cases of normal skin.Results The positive rate of Cyclin D1 in EMPD was 92.86%,which was higher than normal skin tissue(8.33%)(P<0.05).The positive rate of PCNA in EMPD was 89.29%,which was obviously hig... |
| |
| Keywords: | Cyclin D1 PCNA C-erbB-2 EMPD |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
