Phenotypic and functional properties of murine {gamma}{delta} T cell clones derived from malaria immunized, {alpha}{beta} T cell-deficient mice |
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Authors: | Tsuji Moriya; Eyster Cassandra L; O'Brien Rebecca L; Born Willi K; Bapna Mitali; Reichel Martin; Nussenzweig Ruth S; Zavala Fidel |
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Institution: | Department of Medical and Molecular Parasitology, New York University School of Medicine 341 East 25th Street, New York, NY 10010, USA
1 Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine 1400 Jackson Street, Denver, CO 80262, USA |
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Abstract: | Six murine T cell clones expressing ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) TCR were generated frommalaria immunized, ß T celldeficient mice. Phenotypiccharacterization of these clones has revealed that, in contrastto conventional ß T cells, there is a considerabledegree of heterogeneity among these ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) clones with regard to theirsurface markers and their lymphokine profile. One clone wasfound to display significant anti-parasite activity in vivoupon adoptive transfer. We attempted to determine whether theprotective clone differs in one or more key characteristicsfrom the non-protective clones. Although no obvious patternpeculiar to the protective ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) clone was observed, it appears thatmore than one parameter may, in combination, define a distinctprotective phenotype, and thus explain the functional differencebetween the protective and non-protective ![{gamma}](http://intimm.oxfordjournals.org/math/gamma.gif) clones. |
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Keywords: | lipopolysaccharide lymphokine profile malaria murine ![{gamma}](/math/gamma</a> <a href=) gif" ALT="{gamma}" BORDER="0"> T cells" target="_blank">gif" ALT="{delta}" BORDER="0"> T cells surface phenotype TCR |
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