Primary gastric non-Hodgkin's lymphoma: a clinicopathological study of 41 patients |
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Authors: | R Kath K Donhuijsen J Hayungs K Albrecht S Seeber K Höffken |
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Institution: | 1. Department of Internal Medicine (Cancer Research), West German Tumor Center, University of Essen, medical School, Essen, Germany 3. Department of Pathology, West German Tumor Center, University of Essen, Medical School, Essen, Germany 5. Department of Surgery, University of Essen Medical School, Essen, Germany
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Abstract: | Pathological findings in 41 patients (male/female ratio: 1.3/1) with primary localized gastric non-Hodgkin's lymphoma (NHL)
were retrospectively studied and correlated with survival. The median observation period after diagnosis was 32 (0–189) months.
Nineteen patients were low-grade NHL, all but one B-cell lymphomas of the mucosa-associated lymphoid tissue (MALT) type. Twenty-two
patients had primary (n-7) or secondary (n=15) high-grade lymphomas; Musshoff stage IE was found in 29 and II E in 12 cases. The median age at diagnosis was 61 years
(range, 26–88 years), and proliferation, measured by the number of mitosis and Ki-67 antigen positivity (MIB-1), was high
or moderately high in 24 cases and low in 17 cases. Follicular lymphatic hyperplasia could be found in 25 of 34 evaluable
cases, more often in low-grade than in high-grade NHL. Most of the patients were treated by resective surgery and additional
ratio- or chemotherapy. Thirteen patients (31%) died (median survival: 10 months), 5 of them within 3 months after surgery
owing to postoperative complications. Survival was superior, though not statistically significant, in low-grade lymphomas.
Our retrospective anlysis of heterogeneously treated gastric lymphomas reveals that gastric lymphomas, especially of the low-grade
MALT type, often remain a localized disease with a good long-term prognosis. Our study confirms previous reports indicating
that lymphomas of the MALT type represent a specific clinicopathological entity. |
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Keywords: | Gastric lymphoma MALT lymphoma Non-Hodgkin's lymphoma |
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