Association between interleukin-17 gene polymorphisms and risk of coronary artery disease |
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| Authors: | Lian Shuang Zhiliang Li Fengying Chen Xiaoying Cui Yuzhen Ning Youle Su Mei Dong |
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| Institution: | 1.Department of Cardiovascular, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China;2.Department of Emergency, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010051, China;3.Department of Neurosurgery, Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010051, China;4.Department of Orthopedic Medicine, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010030, China |
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| Abstract: | We conducted a case-control study to estimate the association between IL-17A rs2275913, rs3819025 and rs3748067 polymorphisms and development of coronary artery disease. A total of 415 patients with coronary artery disease and 448 health controls were recruited during the period of March 2013 and October 2014. Genotyping of IL-17A rs2275913, rs3819025 and rs3748067 were analyzed by polymerase chain reaction coupled with restriction fragment length polymorphism. By logistic regression analysis, we found that individuals with the AA genotype (OR, 2.18; 95% CI, 1.35-3.56) and the GA+AA genotype (OR, 1.39, 95% CI, 1.06-1.84) of rs2275913 were associated with an increased risk of coronary artery disease when compared with the GG genotype. Individuals carrying the GA+AA genotype of rs2275913 were more likely to have a higher risk of coronary artery disease in those with hypertension and smoking habit, and the adjusted ORs (95% CI) were 3.92 (2.13-6.82) and 2.74 (1.71-4.40). In conclusion, we suggest that individuals with the AA genotype and the GA+AA genotype of rs2275913 are associated with an increased risk of coronary artery disease, especially in those with hypertension and smoking habit. |
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| Keywords: | Interleukin-17 polymorphism coronary artery disease |
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