Comparing the Outcomes of Deceased-Donor and Living-Donor Liver Re-Transplantation In Adult Patients |
| |
| Institution: | 1. Bahçelievler Memorial Hospital, Organ Transplantation Center, Istanbul, Turkey;2. Bahçelievler Memorial Hospital, Department of Gastroenterology, Istanbul, Turkey;1. Liver Transplant Institute, Malatya, Turkey;2. Department Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya, Turkey;3. Department of Medical Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey;4. Fuel-Oil Analysis Laboratory, Inonu University Rectorate, Malatya, Turkey;5. Department of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria;1. Pediatric Nephrology, Ege University Faculty of Medicine, ?zmir, Turkey;2. General Surgery, Ege University Faculty of Medicine, ?zmir, Turkey;3. Pediatrics, Ege University Faculty of Medicine, ?zmir, Turkey;5. Pathology, Ege University Faculty of Medicine, ?zmir, Turkey;1. Department of Cardiovascular Surgery, Near East University Faculty of Medicine, Nicosia, Turkish Republic of Northern Cyprus;2. Department of Cardiovascular Surgery, Ege University Faculty of Medicine, ?zmir, Turkey;1. Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, Turkey;2. Department Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya, Turkey;3. Department of Medical Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey;4. Department of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria;5. King Hussein Medical Center, Royal Medical Services, Amman, Jordan |
| |
| Abstract: | BackgroundPatients with liver graft failures have an extremely low chance of finding a cadaveric graft in countries with a scarcity of deceased donors. We compared the outcomes of liver re-transplantation with living-donor liver grafts (re-LDLT) and deceased-donor liver grafts (re-DDLT) in adult patients (>18 years).MethodsThe medical records of 1513 (1417 93.6%] LDLT and 96 6.3%] DDLT) patients who underwent liver transplantation at Memorial Hospital between January 2011 and October 2022 were reviewed. Forty patients (24 adults and 16 pediatric) were re-transplanted (2.84%); 24 adult patients (2.72%: 25 re-LDLT, 1 patient with second re-LDLT) were divided into 2 groups: re-DDLT (n = 6) and re-LDLT (n = 18). The groups were compared in demographics, pre-, peri-, postoperative characteristics, and outcomes.ResultsThe overall survival rates were 91.7%, 79.2%, 75.0%, and 75% for <30 days, 31 to 90 days, 1, and 3 years, respectively. The LDLT group was significantly younger (P = .022), had smaller graft weight (P = .03), shorter mechanical ventilation (P = .036) but longer operation time (P = .019), and hospitalization period (P = .003). The groups were otherwise comparable. There was no statistically significant difference in survival rates between the groups (P = .058), although the re-LDLT group had an evidently higher survival rate (88.9% and 83.3 % vs 50.0%).ConclusionRe-LDLT has shown comparable outcomes to re-DDLT, if not better (even not far from significance P = .058). These results may encourage performing re-LDLTs in patients with indications for re-LT without worrying about low chances of survival, especially in countries with limited sources of deceased donors. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
