Factors Predicting Over-Time Weight Increase After Liver Transplantation: A Retrospective Study |
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| Affiliation: | 1. Division of Transplantation Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;2. Institute of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan;3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;4. Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan;1. Stem Cell Transplantation and Cellular Therapy Program, Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York;2. Mount Sinai Hospital, New York, New York;3. Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York;4. Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York;1. Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita, Japan;2. Osaka Center for Cancer and Cardiovascular Disease Prevention, Osaka, Japan;1. Department of Urology, Fujita Health University Okazaki Medical Center, Okazaki, Aichi, Japan;2. Department of Urology, Fujita Health University, Toyoake , Aichi, Japan;3. Department of Organ Transplant Surgery, Fujita Health University, Toyoake , Aichi, Japan |
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| Abstract: | BackgroundPost-transplantation weight control is important for long-term outcomes; however, few reports have examined postoperative weight change. This study aimed to identify perioperative factors contributing to post-transplantation weight change.MethodsTwenty-nine patients who underwent liver transplantation between 2015 and 2019 with an overall survival of >3 years were analyzed.ResultsThe median age, model for end-stage liver disease score, and preoperative body mass index (BMI) of the recipients were 57, 25, and 23.7, respectively. Although all but one recipient lost weight, the percentage of recipients who gained weight increased to 55% (1 month), 72% (6 months), and 83% (12 months). Among perioperative factors, recipient age ≤50 years and BMI ≤25 were identified as risk factors for weight gain within 12 months (P < .05), and patients with age ≤50 years or BMI ≤25 recipients gained weight more rapidly (P < .05). The recovery time of serum albumin level ≥4.0 mg/dL was not statistically different between the 2 groups. The weight change during the first 3 years after discharge was represented by an approximately straight line, with 18 and 11 recipients showing a positive and negative slope, respectively. Body mass index ≤23 was identified as a risk factor for a positive slope of weight gain (P <.05).ConclusionsAlthough postoperative weight gain implies recovery after transplantation, recipients with a lower preoperative BMI should strictly manage body weight as they may be at higher risk of rapid weight increase. |
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