Effects of Body Mass Index Changes In Pediatric Kidney Transplant Patients |
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| Institution: | 1. Ege University Faculty of Medicine, Pediatric Nephrology, İzmir, Turkey;2. Ege University Faculty of Medicine, General Surgery, İzmir, Turkey;3. Ege University Faculty of Medicine, Pediatrics, İzmir, Turkey;1. Organ Transplantation Center, Bahçelievler Memorial Hospital, Istanbul, Turkey;2. Department of Pediatric Gastroenterology, Bahçelievler Memorial Hospital, Istanbul, Turkey;1. Department of Thoracic Surgery, School of Medicine, Ege University, Izmir, Turkey;2. Department of Cardiovascular Surgery, School of Medicine, Ege University, Izmir, Turkey;3. Department of Respiratory Diseases, School of Medicine, Ege University, Izmir, Turkey;1. Department of General Surgery, Dokuz Eylül University Hospital, Hepatobiliary Surgery and Liver Transplantation Unit, Izmir, Turkey;2. Department of Anesthesiology and Reanimation, Dokuz Eylül University Hospital, Izmir, Turkey;3. Department of Infectious Diseases, Dokuz Eylül University Hospital, Izmir, Turkey;4. Department of Gastroenterology, Dokuz Eylül University Hospital, Izmir, Turkey;5. Department of Pathology, Dokuz Eylül University Hospital, Izmir, Turkey;6. Department of General Surgery, Güven Hospital, Ankara, Turkey;7. Department of General Surgery, Memorial Bahçelievler Hospital, Istanbul, Turkey;1. Liver Transplant Institute, Malatya, Turkey;2. Department Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya, Turkey;3. Department of Medical Biochemistry, Inonu University Faculty of Medicine, Malatya, Turkey;4. Fuel-Oil Analysis Laboratory, Inonu University Rectorate, Malatya, Turkey;5. Department of Surgery, Aminu Kano Teaching Hospital, Kano, Nigeria |
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| Abstract: | BackgroundThe negative effects of pretransplant obesity and post-transplant body mass index (BMI) increase on graft survival have been reported in recent years. The aim of this study is to evaluate the effects of BMI changes on post-transplant graft function, lipid profile, and blood pressure.MethodsThe study included 133 pediatric patients transplanted between 1994 and 2019 in Ege University. BMI Z-scores (BMIZs) were calculated according to age and sex before and after transplantation using the World Health Organization criteria. Patients with BMIZs >+1 standard deviation (SD) were defined as overweight, and those with BMIZs >+2 SD were defined as obese: Group 1: Obese or overweight before transplantation; Group 2: Thin or normal weight before and 2 years after transplantation; and Group 3: Thin or normal weight before transplantation and obese or overweight 2 years after transplantation.ResultsAt the time of transplantation 8% of the patients were overweight, and 1% were obese. Overweight and obesity statistically significantly increased (31.6%) 2 years after renal transplantation (P = .001). Obese and overweight patients have lower high-density lipoprotein levels and were younger at the time of transplantation. Graft functions, lipid levels, and blood glucose levels of the groups were similar (P > .05). The only significant difference between the groups was that Group 1 patients were younger than Group 2.ConclusionsObesity develops at a significant rate in pediatric patients after renal transplantation. In this study, we could not demonstrate negative effects of obesity and being overweight in terms of post-transplant graft function, lipid profile, blood glucose, and blood pressure. |
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