The natural history of untreated ocular hypertension and glaucoma |
| |
| Affiliation: | 1. Department of Ophthalmology, Faculty of Medicine, University Hospitals Leuven, 3000 Leuven, Belgium;2. Research Group Ophthalmology, Department of Neurosciences, KU Leuven, 3000 Leuven, Belgium;3. Department of Ophthalmology, Centro Hospitalar e Universitário São João, 4200-319 Porto, Portugal;4. Cardiovascular R&D Centre – UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto, 4200-319 Porto, Portugal;5. Department of Ophthalmology, University Hospitals Leuven, 3000 Leuven, Belgium;1. Rome Eye Hospital, Rome, Italy;2. Eye Clinic, Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Public Health Department, University of Naples Federico II, Naples, Italy;3. UOC Ophthalmology and Surgery Department, ASL-1 Avezzano-Sulmona, L''Aquila, Italy;4. Eye Clinic, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy;5. IRCCS-Fondazione Bietti, Rome, Italy;6. Department of Biomedical and Clinical Science “Luigi Sacco”, Eye Clinic, Luigi Sacco Hospital, University of Milan, Milan, Italy;7. Department of Medicine-Ophthalmology, University of Udine, Udine, Italy;8. University Eye Clinic, IRCCS Multimedica, Milan, Italy;9. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy;10. Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;11. Catholic University “Sacro Cuore”, Rome, Italy;1. From the Hamilton Glaucoma Center (T.N., S.M., M.L.M.Y., J.-H.W., V.M., A.K., G.M., M.A.F., L.M.Z., R.N.W.), Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California−San Diego, La Jolla, California, USA;2. Bernard and Shirlee Brown Glaucoma Research Laboratory (J.M.L.), Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Medical Center, New York, New York, USA;3. Heersink School of Medicine (M.A.F., C.A.G.), University of Alabama−Birmingham, Birmingham, Alabama, USA;1. Baylor College of Medicine, Houston, Texas, USA;2. Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA;3. Department of Pathology, Texas Children''s Hospital, Houston, Texas, USA;4. Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA;5. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA;1. Department of Ophthalmology, “Santo Spirito” Hospital, Pescara (PE), Italy;2. Division of Neuro-Ophthalmology, Baylor College of Medicine, Houston, Texas, USA;1. Department Of Ophthalmology, University of Alabama at Birmingham, Birmingham, AL, USA;2. Department Of Ophthalmology, Wills Eye Hospital, USA;1. Department of Ophthalmology, Maulana Azad Medical College, New Delhi, India;2. Department of Ophthalmology, National University Hospital, Kent Ridge, Singapore;3. Department of Radiology, Maulana Azad Medical College, New Delhi, India |
| |
| Abstract: | Glaucoma is a chronic, progressive disease leading to irreversible blindness if left untreated; however, since reducing intraocular pressure has proven to be successful in slowing disease progression, little is known about the natural history of untreated glaucoma. This knowledge can be valuable in guiding management decisions in the era of personalized medicine. A systematic search was performed in Medline (PubMed), Embase, and Web of Science in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRIMSA) guidelines. The rate of structural and/or functional progression and conversion to glaucoma or to a more advanced stage of glaucoma are discussed for ocular hypertension and different types of open-angle glaucoma. Forty-three studies were included. Different rates of progression were found both among and within the different diagnostic groups that belong to the open-angle glaucoma spectrum. The highest rate was found in pseudoexfoliation glaucoma, followed by high tension glaucoma, normal tension glaucoma, and ocular hypertension, in decreasing order. The lowest rate was observed in glaucoma suspects. The known rates of progression provide valuable prognostic information for ophthalmologists and patients. Nonetheless, due to high variability among patients, individual progression cannot be accurately predicted and repeated follow-up examinations are required to estimate individual progression. |
| |
| Keywords: | Untreated IOP" },{" #name" :" keyword" ," $" :{" id" :" pc_HyOg3lwI6v" }," $$" :[{" #name" :" text" ," _" :" Intraocular pressure OCT" },{" #name" :" keyword" ," $" :{" id" :" pc_aDmDYa6Dpk" }," $$" :[{" #name" :" text" ," _" :" Optical coherence tomography RNFL" },{" #name" :" keyword" ," $" :{" id" :" pc_OQAah3ZWav" }," $$" :[{" #name" :" text" ," _" :" Retinal nerve fiber layer HRT" },{" #name" :" keyword" ," $" :{" id" :" pc_DWbB5eKUqi" }," $$" :[{" #name" :" text" ," _" :" Heidelberg Retina Tomography HFA" },{" #name" :" keyword" ," $" :{" id" :" pc_U6ELhVfeA9" }," $$" :[{" #name" :" text" ," _" :" Humphrey Field Analyzer SAP" },{" #name" :" keyword" ," $" :{" id" :" pc_69SlXjikfq" }," $$" :[{" #name" :" text" ," _" :" Standard automated perimetry MD" },{" #name" :" keyword" ," $" :{" id" :" pc_BwxmjZ8fMo" }," $$" :[{" #name" :" text" ," _" :" Mean deviation PERG" },{" #name" :" keyword" ," $" :{" id" :" pc_5Vi8UZRhrc" }," $$" :[{" #name" :" text" ," _" :" Pattern electroretinogram OHT" },{" #name" :" keyword" ," $" :{" id" :" pc_lOorWRIP3n" }," $$" :[{" #name" :" text" ," _" :" Ocular hypertension OAG" },{" #name" :" keyword" ," $" :{" id" :" pc_2T9YQPlQk0" }," $$" :[{" #name" :" text" ," _" :" Open-angle glaucoma NTG" },{" #name" :" keyword" ," $" :{" id" :" pc_q4TaILylUk" }," $$" :[{" #name" :" text" ," _" :" Normal tension glaucoma PEXG" },{" #name" :" keyword" ," $" :{" id" :" pc_lJ7WQigD9Z" }," $$" :[{" #name" :" text" ," _" :" Pseudoexfoliation glaucoma HTG" },{" #name" :" keyword" ," $" :{" id" :" pc_PwbrFlnvC9" }," $$" :[{" #name" :" text" ," _" :" High tension glaucoma AGIS" },{" #name" :" keyword" ," $" :{" id" :" pc_QhMJWvFjt4" }," $$" :[{" #name" :" text" ," _" :" Advanced Glaucoma Intervention Study EGPS" },{" #name" :" keyword" ," $" :{" id" :" pc_vsqTOhmrQz" }," $$" :[{" #name" :" text" ," _" :" European Glaucoma Prevention Study OHTS" },{" #name" :" keyword" ," $" :{" id" :" pc_z1Gqjx6QwJ" }," $$" :[{" #name" :" text" ," _" :" Ocular Hypertension Treatment Study CNTGS" },{" #name" :" keyword" ," $" :{" id" :" pc_bZi1hVKXTu" }," $$" :[{" #name" :" text" ," _" :" Collaborative Normal Tension Glaucoma Study Group EMGT" },{" #name" :" keyword" ," $" :{" id" :" pc_2KTXpG51S9" }," $$" :[{" #name" :" text" ," _" :" Early Manifest Glaucoma Trial UKGTS" },{" #name" :" keyword" ," $" :{" id" :" pc_HBDeBDwYFD" }," $$" :[{" #name" :" text" ," _" :" United Kingdom Glaucoma Treatment Study CIGTS" },{" #name" :" keyword" ," $" :{" id" :" pc_X7dVN4Ng1v" }," $$" :[{" #name" :" text" ," _" :" Collaborative Initial Glaucoma Treatment Study PRISMA" },{" #name" :" keyword" ," $" :{" id" :" pc_JSZ7Lkdm9P" }," $$" :[{" #name" :" text" ," _" :" Preferred Reporting Items for Systematic Reviews and Meta-Analyses |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
