Transmission du cytomégalovirus par le lait maternel cru aux enfants prématurés : étude épidémiologique pilote |
| |
| Institution: | 1. Unités de réanimation et néonatalogie, département de pédiatrie, CHU Morvan, 2, avenue Foch, 29609 Brest cedex, France;2. EA 3882 biodiversité et écologie microbienne, département de microbiologie, CHU Morvan, 2, avenue Foch, 29609 Brest cedex, France;1. Section of Immunology, Wright-Fleming Institute, Imperial College, London, United Kingdom;;2. Imperial Molecular Pathology Laboratory, Imperial College Healthcare NHS Trust and Academic Health Sciences Centre, Hammersmith Hospital, London, United Kingdom;;3. Centre for Haematology, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom;;4. Section of Virology, Wright-Fleming Institute, Imperial College, London, United Kingdom; and;5. Institute for Viral Research, Kyoto University, Kyoto, Japan;1. Infectious Disease Control Division, Health Service Bureau, Ministry of Health, Labour and Welfare, Tokyo 100–8916, Japan;1. Department of Sciences for Health Promotion and Mother and Child Care, Pediatric Unit, University of Palermo, Palermo, Italy;2. Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Italy;3. Euro-Mediterranean Institute of Science and Technology, Palermo, Italy;4. Department of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, Italy;5. Department of Biomedical and Biotechnological Sciences, University of Catania, Italy;1. Key Laboratory of Geographic Information Science, East China Normal University, China;2. University of Texas at Dallas, Richardson, TX 75080, USA;1. Service de pédiatrie, centre hospitalier national Abass Ndao, Dakar, Sénégal;2. Service de pédiatrie, centre hospitalier universitaire (CHU) Aristide le Dantec, BP 3001 Dakar-Fann, Sénégal |
| |
| Abstract: | Transmission of cytomegalovirus (CMV) infection from mothers to preterm infants during breastfeeding may be symptomatic and long term consequences are unknown. This study evaluated the kinetics of CMV load in breastmilk and the rate of postnatal CMV transmission via breastmilk from mothers to their preterm infants.MethodsProspective study of mother-child pairs after preterm delivery before 33 weeks. Exclusion of donor breast milk and of CMV-seropositive blood products. Material used was maternal CMV serostatus, ear swab of the infant at birth, weekly screened breast milk and children's urine by rapid viral culture.ResultsDuring a 5-month period 28 mother-infant pairs with 34 preterm infants were studied. Eighteen women (64.3%) were CMV-seronegative at birth; breastmilk samples and the infants' urine remained CMV-negative. Eight of the 10 seropositive mothers, who had 11 preterm infants, excreted CMV into breast milk (80%). CMV excretion into breast milk was detected during the first week after delivery in 66% cases and was at its peaked between 3 to 5 weeks after delivery. Out of the 7 CMV-exposed infants, CMV transmission was confirmed in only one asymptomatic case. Total quantity of breast milk intake did not seem discriminative for CMV transmission.ConclusionIn CMV-seropositive mothers of preterm infants a high incidence of CMV excretion into breast milk was detected. Despite this high rate, symptomatic infection did not occur. However, potential risk and severity of infection may be difficult to establish. Because breastfeeding is beneficial, new procedures for gentle virus inactivation of seropositive breast milk should be assessed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
