Histopathological Evaluation of Gallbladder Specimens Obtained From Living Liver Donors |
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| Institution: | 1. Department of Surgery and Liver Transplant Institute, Inonu University Faculty of Medicine, Malatya, Turkey;2. Department of Biostatistics and Medical Informatics, Inonu University Faculty of Medicine, Malatya, Turkey;3. Department of Pathology, Inonu University Faculty of Medicine, Malatya, Turkey;1. Department of Nephrology, Saraswati Kidney Care Center, Nagpur, Maharashtra, India;2. Department of Nephrology, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India;3. Department of Nephrology, AIIMS, Nagpur, Maharashtra, India;4. Department of Internal Medicine, Jawaharlal Nehru Medical College, Sawangi, Wardha, Maharashtra, India;5. Department of Clinical Research, Saraswati Kidney Care Center, Nagpur, Maharashtra, India;6. and Avanvi Research and Technologies Pvt Ltd, Nagpur, Maharashtra, India;1. Department of Cardiovascular Surgery, Near East University Faculty of Medicine, Nicosia, Turkish Republic Northern Cyprus;2. Department of Cardiovascular Surgery, Ege University Faculty of Medicine, İzmir, Turkey;1. Department of Nephrology, Vardhaman Mahavir Medical College & Safdarjung Hospital, Delhi, India;2. Department of Pathology, Vardhaman Mahavir Medical College & Safdrajung Hospital, Delhi, India;1. Department of Infectious Diseases and Clinical Microbiology, Dokuz Eylul University Faculty of Medicine, Inciraltı, Izmir, Turkey;2. Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Inciraltı, Izmir, Turkey;3. Department of Pulmonary Diseases, Dokuz Eylul University Faculty of Medicine, Inciraltı, Izmir, Turkey |
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| Abstract: | BackgroundCholecystectomy is routinely performed during living donor hepatectomy both to see the structure of the biliary tract and to determine the demarcation line based on the biliary tract junction. This study aims to present the general histopathological features of the gallbladder specimen obtained from living liver donors (LLD).MethodsData from 2577 LLDs who underwent living donor hepatectomy (n = 2511) or aborted living donor hepatectomy (n = 66) in our Liver Transplantation Institute between September 2005 and June 2021 were analyzed retrospectively. Age, gender, macroscopic (length, diameter, and wall thickness), and microscopic (histopathological) features of the gallbladder of the LLDs were recorded for use in this study.ResultsA total of 2493 LLDs (men: 1486, women: 1007) with a median age of 29 years (interquartile range IQR]: 13) met the inclusion criteria in this study. The median length, width and wall thickness of the gallbladder specimens were measured as 70 mm (IQR: 20), 50 mm (IQR: 20), and 2 mm (IQR: 1), respectively. The most common histopathological findings are normal structure (2026; 81.3%), chronic cholecystitis (n = 446; 17.9%), adenomyomatosis (n = 9), and papillary hyperplasia (n = 6), respectively. The most common pathologic findings in the gallbladder lumen are cholesterolosis (n = 207; 0.4%), cholelithiasis (n = 53), cholesterol polyp (n = 31), and noncholesterol polyp (n = 19), respectively. Significant differences were detected between the male and female genders in terms of age (P < .001), height (P < .001), weight (P < .001), body mass index (P < .001), gallbladder width (P = .001), gallbladder length (P < .001), histopathological finding (content) (P < .001), and lymph node around the gallbladder (P = .015).ConclusionsThe results we obtained in this study are true gallbladder pathologies that can be detected in healthy people. In this study, it was shown that the diameter and size of the gallbladder were larger in men, whereas the incidence of cholesterolosis and cholelithiasis was higher in women. |
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