Comprehensive Analysis of Donor Factors for Allograft Survival in Living Kidney Transplantation: A Single-Center Study in Japan |
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| Affiliation: | 1. Private Inova Hospital, Urology, Aksaray, Turkey;2. Asklepios Klinik Triberg, Urology, Triberg, Germany;3. University of Health Sciences, Ankara City Hospital, Department of Urology, Ankara, Turkey;4. Bingol State Hospital, Department of Urology, Bingol, Turkey;1. Department of Surgery, University of Illinois at Chicago, Illinois;2. Department of Pathology, University of Illinois at Chicago, Illinois;3. Department of Pharmacy Practice, University of Illinois at Chicago, Illinois;1. Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada;2. Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada;3. Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada;4. Beatrice Hunter Cancer Research Institute, Halifax, Nova Scotia, Canada;1. Ribeirao Preto Medical School at University of São Paulo (FMRP/USP), Ribeirao Preto, SP, Brazil;3. Estácio University Center of Ribeirão Preto (UniSEB), Ribeirão Preto, SP, Brazil;4. and Ministry of Health, Brasilia, DF, Brazil;1. Department of Urology, Fujita Health University Okazaki Medical Center, Okazaki, Aichi, Japan;2. Department of Urology, Fujita Health University, Toyoake , Aichi, Japan;3. Department of Organ Transplant Surgery, Fujita Health University, Toyoake , Aichi, Japan |
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| Abstract: | BackgroundVarious donor characteristics have been reported as predictive factors for graft survival in kidney transplantations. The living kidney donor profile index (LKDPI) was established in 2016 to evaluate the quality of living donor kidneys. Herein, we verified whether the index score was associated with graft survival and analyzed various donor factors to identify predictors of graft survival in living donor kidney transplantations.MethodsThis retrospective study included 130 patients who received a living donor kidney between 2006 and 2019 at our hospital. Clinical and laboratory data were obtained from the medical records. Living donor kidneys were categorized into 3 groups by LKDPI score, and the death-censored graft survival and predictors of graft survival were evaluated.ResultsThe median LKDPI score was 35 (IQR: 17-53). The index scores of the living donor kidneys in this study were higher than in previous studies. The groups with the highest scores (LKDPI >40) had significantly shorter death-censored graft survival compared with the group with the lowest scores (LKDPI <20; hazard ratio = 4.0, P = .005). There were no significant differences between the group with the middle scores (LKDPI, 20-40) and the other 2 groups. Donor/recipient weight ratio <0.9, ABO incompatibility, and 2 HLA-DR mismatches were identified as independent predictive factors for shorter graft survival.ConclusionThe LKDPI was correlated with death-censored graft survival in this study. However, more studies are required to establish a modified index that is more accurate for Japanese patients. |
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