脑还丹胶囊治疗老年痴呆的临床研究

目的：探讨脑还丹胶囊治疗老年痴呆的临床疗效。方法：将符合美国精神病学会《精神障碍诊断与统计手册》（DSM－Ⅳ）诊断标准的老年痴呆患者58例,随机分为脑还丹组30例,脑复康对照组28例,分别采用脑还丹胶囊和脑复康片（吡拉西坦）治疗,疗程3月。采用简易精神状态检查表（MMSE）和日常生活自理能力量表（ADL）积分的变化进行疗效评估,检测患者血清雌二醇（E2）、睾酮（T）、E2／T比值,及血脂、血液流变学等水平变化。结果：脑还丹胶囊能提高E2和T水平,降低E2／T比值（P＜0．05）;能降低血脂,改变血液流变学,脑还丹组总有效率66．7％,对照组60．8％,2组比较差异无显著性（P＞0．05）;MMSE和ADL治疗前后差值比较,脑还丹组均优于对照组（P＜0．05和P＜0．01）。结论：脑还丹胶囊对老年痴呆有较好的防治作用,其机制与提高E2、T水平,降低E2／T比值及调节神经内分泌功能有关。

Clinical study on naohuandan capsule in the treatment of senile dementia

Objective To explore the efficacy of Naohuandan capsule in treating senile dementia. Methods Fifty-eight patients selected according to the diagnostic standard of American Association of Psychiatry(DSM-IV) were randomly divided into 2 groups for a 3-month treatment course.Group A(n=30) was treated with Naohuandan capsule and group B (n=28) with naofukang tablet.Efficacy was evaluated by mini-mental state examination(MMSE) and activity of daily living (ADL) Score and serum levels of estradiol(E 2) and testosterone(T),hemorrheologic characters and blood lipid. Results Scores of MMSE and ADL were incresed,E 2 and T levels were elevated and E 2/T was decreased in group A(P<0.05,versus Group B).Naohunandan capsule can decrease blood lipid and improve the hemorrheology.The total effective ratio was 66.7% in group A and 60.8% in group B,with nonsignificant difference(P>0.05). Conclusions Naohuandan capsule has definite effect in prevention and treating senile dementia and its mechanism may be related to increase of E 2 and T,decrease the rate of E 2/T and the regulation of neuroendocrine function.