Genetic variability in CYP3A4 and CYP3A5in primary liver,gastric and colorectal cancer patients |
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| Authors: | Guillermo Gervasini Elena García-Martín José M Ladero Rosa Pizarro Javier Sastre Carmen Martínez Monserrat García Manuel Diaz-Rubio José AG Agúndez |
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| Affiliation: | 1.Department of Pharmacology & Psychiatry,University of Extremadura,Badajoz,Spain;2.Department of Biochemistry & Molecular Biology & Genetics,University of Extremadura,Badajoz,Spain;3.Service of Gastroenterology, Hospital Clínico San Carlos,Complutense University,Madrid,Spain;4.Service of Oncology Hospital Clínico San Carlos,Complutense University,Madrid,Spain |
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| Abstract: | Background Drug-metabolizing enzymes play a role in chemical carcinogenesis through enzymatic activation of procarcinogens to biologically reactive metabolites. The role of gene polymorphisms of several cytochrome P450 enzymes in digestive cancer risk has been extensively investigated. However, the drug-metabolizing enzymes with the broader substrate specificity, CYP3A4 and CYP3A5, have not been analyzed so far. This study aims to examine associations between common CYP3A4 and CYP3A5 polymorphisms and digestive cancer risk. |
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