阻塞性睡眠呼吸暂停低通气综合征合并2型糖尿病患者血清Nesfatin-1的变化及意义

目的　探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）合并2型糖尿病（type 2 diabetes mellitus，T2DM）患者血清Nesfatin-1的变化及意义。方法　收集2014年12月～2015年4月就诊于我院耳鼻咽喉科、呼吸科、内分泌科、体检中心及睡眠监测室的25例OSAHS患者（OSAHS组）、OSAHS合并T2DM患者（OSAHS合并T2DM组）和25例对照组为研究对象。所有受试者均进行整夜7h的多道睡眠图监测，并测量研究对象的身高、腰围、颈围、体质量指数（BMI），检测各组血清Nesfatin-1水平和空腹血糖（Fasting blood glucose，FBG）水平。结果　各组性别、年龄、身高、腰围、颈围无统计学差异。与对照组比较，OSAHS组和OSAHS合并T2DM组体重及BMI差异具有统计学意义（P <0.05）；OSAHS合并T2DM组与OSAHS组FPG高于对照组，且OSAHS合并T2DM组高于OSAHS组，且均有统计学差异（P <0.05）；OSAHS合并T2DM组AHI高于OSAHS组，且均有统计学差异（P <0.05）；OSAHS合并T2DM组和OSAHS组血清Nesfatin-1含量高于对照组，且有统计学差异（P <0.05）；FPG、AHI与Nesfatin-1呈正相关。结论　OSAHS合并T2DM患者血清Nesfatin-1存在较高的水平。

Changes and clinical significance of serum Nesfatin-1 in patients with obstructive sleep apnea hypopnea syndrome and type 2 diabetes mellitus

OBJECTIVE To investigate the changes and clinical significance of serum Nesfatin-1 in patients with obstructive sleep apnea hypopnea syndrome(OSAHS) and type 2 diabetes mellitus (T2DM).METHODS 25 OSAHS cases who visited the department of otolaryngology, pneumology department, endocrinology department, physical examination center and sleep monitoring room from December 2014 to April 2015 were assigned as OSAHS group, and 25 patients with OSAHS and T2DM as OSAHS combination T2DM group, and 25 other patients as control group. All patient were took polysomnography, and the height, waist, neck circumference and BMI with all subjects were recorded. The serum Nesfatin-1 and fast blood glucose levels of all patients were measured.RESULTS The gender, age, height, waist and neck circumference had no statistical difference among all groups. The height and BMI in OSAHS group and OSAHS combination T2DM group were statistically significant difference compared with the control group (P<0.05); the FBG in OSAHS combination T2DM group and OSAHS group were significantly higher than that of the control group, and the FBG in OSAHS combination T2DM group were significantly higher than that of the OSAHS group, with statistically significant(P<0.05); The AHI in OSAHS combination T2DM group were significantly higher than that of the OSAHS group, with statistically significant(P<0.05); the serum Nesfatin-1 in OSAHS combination T2DM group and OSAHS group were significantly higher than that of the control group, with statistically significant(P<0.05); FBG, AHI and Nesfatin-1 were positively correlated with each other.CONCLUSION The serum Nesfatin-1 in patients with OSAHS combination T2DM are in a high level.