| 舌下与普通硝苯地平片血药浓度测定与药物动力学研究 |
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| 引用本文： | 李杰,何文明,严宝霞,阎高毅. 舌下与普通硝苯地平片血药浓度测定与药物动力学研究[J]. 中国临床药学杂志, 1994, 0(2) |
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| 作者姓名： | 李杰 何文明 严宝霞 阎高毅 |
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| 作者单位： | 北京医科大学第三医院药剂科 100083(李杰，何文明，严宝霞)，北京医科大学第三医院药剂科 100083(阎高毅) |
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| 摘 要： | 本文用毛细管气相色谱法(GC-ECD)测定了血清中硝苯地平浓度。并对9名受试者服20mg硝苯地平舌下片和国产普通片的药物动力学进行了比较研究。舌下片、普通片主要动力学参数为:ka=7.55、2.08~(-1)、ke=0.31、0.21h~(-1);V/F=0.16、0.29ml/mg;Tpeak=1.68、2.27h;C_(max)=100.05、58.08ng/ml。结果舌下片吸收快、峰浓度高、起效时间明显提前。
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| 关 键 词： | 硝苯地平 舌下片 毛细管气相色谱 药物动力学 |
BLOOD CONCENTRATION DETERMINATION AND CLINICAL PIIARMACOKINETIC STUDIES ON ORAL NIFEDIPINE SUBLINGUAL AND CONVENTIONAL TABLET |
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| Li Jie He Wen ming Yan Bao xia Yan Gao yi. BLOOD CONCENTRATION DETERMINATION AND CLINICAL PIIARMACOKINETIC STUDIES ON ORAL NIFEDIPINE SUBLINGUAL AND CONVENTIONAL TABLET[J]. Chinese Journal of Clinical Pharmacy, 1994, 0(2) |
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| Authors: | Li Jie He Wen ming Yan Bao xia Yan Gao yi |
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| Abstract: | Serum nifedipine concentrations were determined by GC-ECD. The pharmacokinetic comparison was made between orel nifedipine sublingual and conventional tablet at a dose of 20mg in 9 volunteers. The pharmacokinstic parameters of sub-lingual and conventional tablet are: Ka = 7. 55,2. 08 h-1;Ke=0. 31h-1,0. 21; V/F = 0. 16,0. 29 ml/mg;Tpeak=1. 68,2. 27 h;Cmax=100. 05,58. 08 ng/ml respctively. The results showed that onset for sublingual tablet had a more rapid onset than conventional. The peak concentration of sublingual was higher than conventional tablet. |
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| Keywords: | nifedipine sublingual tablet GC-ECD pharmacokinetic |
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