| 胎盘组织中促肾上腺皮质激素释放激素的免疫组化研究 |
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| 引用本文： | 贺茜,沙金燕,张黎明,陈雄. 胎盘组织中促肾上腺皮质激素释放激素的免疫组化研究[J]. 第二军医大学学报, 2000, 21(12): 1152-1154 |
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| 作者姓名： | 贺茜 沙金燕 张黎明 陈雄 |
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| 作者单位： | 1. 第二军医大学长海医院妇产科,上海,200433
2. 海军医学系防化医学教研室 |
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| 基金项目： | 国家自然科学基金资助项目! (396 70 75 7) |
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| 摘 要： | 目的：了解胎盘组织中促肾上腺皮质激素释放激素（ＣＲＨ）的表达量与分布，获取孕妇外周血中高浓度ＣＲＨ来源于胎盘的直接证据。方法：采用免疫组织化学ＬＳＡＢ法显示胎盘组织中ＣＲＨ的表达量及其分布。结果：早期绒毛合体滋层细胞ＣＲＨ表达量较低，呈弱阳性；中期引产的胎盘组织合体滋养层细胞ＣＲＨ表达量有所增加，呈弱阳性至阳性不等；晚期胎盘组织合体滋养层细胞ＣＲＨ表达量进一步增加，均呈强阳性。结论：妊娠晚期及分娩
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| 关 键 词： | 促肾上腺皮质激素释放激素 胎盘 免疫组织化学 |
Immunohistochemistry identification of corticotropin-releasing hormone positive cells from the human placenta |
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| HE Qian,SHA Jin-Yan,ZHANG Li-Ming,CHEN Xiong. Immunohistochemistry identification of corticotropin-releasing hormone positive cells from the human placenta[J]. Former Academic Journal of Second Military Medical University, 2000, 21(12): 1152-1154 |
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| Authors: | HE Qian SHA Jin-Yan ZHANG Li-Ming CHEN Xiong |
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| Abstract: | Objective: To identify corticotropin releasing hormone(CRH) positive cells from the human placenta. Methods: Using immunohistochemistry to show the cellular expression of placental CRH. Results: During human pregnancy, placental CRH level rose markedly from undetectable amounts prior to 20 weeks gestation to nearly the peak level. Conclusion: The presence of CRH in maternal plasma is attributed to the placental production and subsequent release of this hormone into the maternal circulation. [ |
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| Keywords: | corticotropin releasing hormone placenta immunohistochemistry |
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