| 亚砷酸钠亚慢性染毒对小鼠肝脏肾脏的损伤作用 |
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| 引用本文： | 姚芹,吴顺华,汤红英,马艳,吴军,张杰.亚砷酸钠亚慢性染毒对小鼠肝脏肾脏的损伤作用[J].新疆医科大学学报,2010,33(12). |
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| 作者姓名： | 姚芹 吴顺华 汤红英 马艳 吴军 张杰 |
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| 作者单位： | 新疆医科大学公共卫生学院劳动卫生与环境卫生学教研室; |
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| 基金项目： | 新疆维吾尔自治区自然科学基金，教育部博士点专项基金，新疆维吾尔自治区高校科研计划 |
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| 摘 要： | 目的 了解亚砷酸钠亚慢性染毒对小鼠不同脏器的毒性作用及砷在不同脏器中的蓄积情况.方法 采用亚慢性毒性实验方法.昆明种小鼠60 只,按体重随机分成正常对照组(C)、低剂量组(L)、中剂量组(M) 和高剂量组(H) 4组,每组15只,分别自由饮用蒸馏水及0.125 mg/kg、0.5 mg/kg 和2.0 mg/kg 的亚砷酸钠水溶液,连续染毒90 d,实验结束后光镜下对各组小鼠肝脏和肾脏进行组织学观察,采用火焰原子吸收法检测小鼠肝、肾组织砷含量.结果 不同剂量的亚砷酸钠能破坏小鼠肝、肾脏器的正常结构,肝脏和肾脏组织砷含量随着砷染毒剂量的增加而增加(P<0.01).结论 小鼠经不同剂量的亚砷酸钠染毒90 d后,可出现肝脏、肾脏等脏器损伤,推测砷在脏器的蓄积是造成损害作用的物质基础.
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| 关 键 词： | 亚砷酸钠 肝脏 肾脏 |
Damage effects of sodium arsenite on liver and kidney in mice |
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| YAO Qin,WU Shun-hua,TANG Hong-ying,et al.Damage effects of sodium arsenite on liver and kidney in mice[J].Journal of Xinjiang Medical University,2010,33(12). |
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| Authors: | YAO Qin WU Shun-hua TANG Hong-ying |
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| Institution: | YAO Qin,WU Shun-hua,TANG Hong-ying,et al(Department of Occupational and Environmental Health,College of Public Health,Xinjiang Medical University,Urumqi 830011,China) |
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| Abstract: | Objective To investigate the effects and accumulation of sodium arsenite on liver and kidney in mice.Methods Subchronic toxicity experiment was applied.The mouse were randomly separated into four groups of 40 mice,including control group(C),low dose arsenic poisoning group(L),middle dose arsenic poisoning group(M),and high dose arsenic poisoning group(H).Mouse of control group were fed with distilled water.Mouse in group L,group M and group H were fed with water which was dissolved with sodium arsenic at th... |
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| Keywords: | sodium arsenite liver kidney |
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